Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Y Lee, E Puumala, N Robbins, LE Cowen - Chemical reviews, 2020 - ACS Publications
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …

Candida auris: Epidemiology, Diagnosis, Pathogenesis, Antifungal Susceptibility, and Infection Control Measures to Combat the Spread of Infections in Healthcare …

S Ahmad, W Alfouzan - Microorganisms, 2021 - mdpi.com
Candida auris, a recently recognized, often multidrug-resistant yeast, has become a
significant fungal pathogen due to its ability to cause invasive infections and outbreaks in …

Collateral sensitivity counteracts the evolution of antifungal drug resistance in Candida auris

H Carolus, D Sofras, G Boccarella, S Jacobs… - Nature …, 2024 - nature.com
Antifungal drug resistance represents a serious global health threat, necessitating new
treatment strategies. Here we investigated collateral sensitivity (CS), in which resistance to …

[HTML][HTML] The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris

JM Rybak, CA Cuomo, PD Rogers - Current opinion in microbiology, 2022 - Elsevier
Highlights•C. auris exhibits resistance to multiple antifungal agents and represents a public
health threat.•The molecular mechanisms of antifungal resistance observed in C. auris vary …

Review on Antifungal Resistance Mechanisms in the Emerging Pathogen Candida auris

F Chaabane, A Graf, L Jequier, AT Coste - Frontiers in microbiology, 2019 - frontiersin.org
Candida auris is an emerging multi-drug resistant yeast, that causes major issues regarding
patient treatment and surface disinfection in hospitals. Indeed, an important proportion of C …

The quiet and underappreciated rise of drug-resistant invasive fungal pathogens

A Arastehfar, C Lass-Flörl, R Garcia-Rubio… - Journal of Fungi, 2020 - mdpi.com
Human fungal pathogens are attributable to a significant economic burden and mortality
worldwide. Antifungal treatments, although limited in number, play a pivotal role in …

Genome-wide analysis of experimentally evolved Candida auris reveals multiple novel mechanisms of multidrug resistance

H Carolus, S Pierson, JF Muñoz, A Subotić, RB Cruz… - MBio, 2021 - Am Soc Microbiol
Candida auris is globally recognized as an opportunistic fungal pathogen of high concern,
due to its extensive multidrug resistance (MDR). Still, molecular mechanisms of MDR are …

Candida auris and multidrug resistance: Defining the new normal

SR Lockhart - Fungal Genetics and Biology, 2019 - Elsevier
Candida auris is an emerging species of yeast characterized by colonization of skin,
persistence in the healthcare environment, and antifungal resistance. C. auris was first …

On the emergence, spread and resistance of Candida auris: host, pathogen and environmental tipping points

A Chakrabarti, P Sood - Journal of medical microbiology, 2021 - microbiologyresearch.org
Over a decade ago, a multidrug-resistant nosocomial fungus Candida auris emerged
worldwide and has since become a significant challenge for clinicians and microbiologists …

Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris

JM Rybak, JF Muñoz, KS Barker, JE Parker… - MBio, 2020 - Am Soc Microbiol
Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern.
Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most …