The Ron receptor is a member of the Met family of cell surface receptor tyrosine kinases and
is primarily expressed on epithelial cells and macrophages. The biological response of Ron …

The product of the RON (recepteur d'origine nantais) gene belongs to the MET proto-
oncogene family, a distinct subfamily of receptor tyrosine kinases. The ligand of RON was …

Angiotensin II (Ang II)–stimulated hypertrophy of vascular smooth muscle cells is mediated
by reactive oxygen species (ROS) derived from NAD (P) H oxidases. The upstream …

Maintenance of cell and tissue homeostasis is dependent upon the dynamic balance of cell
proliferation, differentiation, and apoptosis through interactions between cells and their …

Background Fertile women may be encouraged to use contraception during clinical trials to
avoid potential drug effects on fetuses. However, hormonal contraception interferes with …

Tumor associated macrophages (TAMs) play a major role in regulating mammary tumor
growth and in directing the responses of tumor infiltrating leukocytes in the …

IL-12, produced by APCs during the initial stages of an immune response, plays a pivotal
role in the induction of IFN-γ by NK and γδT cells and in driving the differentiation of Th1 …

Previous studies demonstrated that targeted deletion of the Ron receptor tyrosine kinase
(TK) domain in mice leads to marked hepatocyte protection in a well‐characterized model of …

Ron receptor kinase (MST1R) is important in promoting epithelial tumorigenesis, but the
potential contributions of its specific expression in stromal cells have not been examined …

Macrophage Stimulating Protein (MSP) is the only known ligand for the receptor tyrosine
kinase Ron. The MSP/Ron pathway is involved in several important biological processes …