Conspectus The advent of photochemical techniques has revolutionized the landscape of
biology and medical sciences. Especially appealing in this context is photodynamic therapy …

Combination therapy, a treatment modality that combines two or more therapeutic agents, is
a cornerstone of cancer therapy. The amalgamation of anti-cancer drugs enhances efficacy …

Drug delivery systems (DDS) triggered by local microenvironment represents the state-of-art
of nanomedicine design, where the triggering hallmarks at intracellular and subcellular …

Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

Carbonic anhydrases (CAs), a group of ubiquitously expressed metalloenzymes, are
involved in numerous physiological and pathological processes, including …

Carbonic anhydrase IX (CAIX) is a hypoxia and HIF-1–inducible protein that regulates intra-
and extracellular pH under hypoxic conditions and promotes tumor cell survival and …

Hypoxia, a characteristic feature of locally advanced solid tumors, has emerged as a pivotal
factor of the tumor (patho-) physiome since it can promote tumor progression and resistance …

The tumor microenvironment includes a complicated network of physiological gradients
contributing to plasticity of tumor cells and heterogeneity of tumor tissue. Hypoxia is a key …