Objective We investigated the comparative efficacy and tolerability of pharmacological
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …

Objective: The role of antidepressants in the acute treatment of bipolar depression remains a
contentious issue. A previous meta-analysis of randomized controlled trials (RCTs) …

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

Page 1 Supplement to THE AMERICAN JOURNAL OF PSYCHIATRY Official Journal of the
AMERICAN PSYCHIATRIC ASSOCIATION Volume 159 Number 4 April 2002 PRACTICE for the …

Depression is one of the most common and debilitating psychiatric disorders and is a
leading cause of suicide. Most people who become depressed will have multiple episodes …

Since 1975, Robert Julien's A Primer of Drug Action has been the definitive guide to the
effects of psychoactive drugs on the brain and on behavior. Now fully updated, this popular …

Family-focused psychoeducational treatment (FFT) is among a very small number of
psychosocial treatments that have been found to be effective in multiple studies to improve …

Objectives. These guidelines are based on a first edition that was published in 2002, and
have been edited and updated with the available scientific evidence until September 2009 …

Bipolar, or manic-depressive, disorder is a frequent, severe, mostly recurrent mood disorder
associated with great morbidity. The lifetime prevalence of bipolar disorder is 1· 3 to 1· 6 …

Objective This study examined the risk of antidepressant-induced manic switch in patients
with bipolar disorder treated either with antidepressant monotherapy or with an …