Pathophysiology of atherosclerosis
S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …
The role of inflammation in cardiovascular disease
MY Henein, S Vancheri, G Longo… - International journal of …, 2022 - mdpi.com
Atherosclerosis is a chronic inflammatory disease, in which the immune system has a
prominent role in its development and progression. Inflammation-induced endothelial …
prominent role in its development and progression. Inflammation-induced endothelial …
Inflammation during the life cycle of the atherosclerotic plaque
P Libby - Cardiovascular Research, 2021 - academic.oup.com
Inflammation orchestrates each stage of the life cycle of atherosclerotic plaques. Indeed,
inflammatory mediators likely link many traditional and emerging risk factors with …
inflammatory mediators likely link many traditional and emerging risk factors with …
Crosstalk between mechanotransduction and metabolism
P Romani, L Valcarcel-Jimenez, C Frezza… - … Reviews Molecular Cell …, 2021 - nature.com
Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …
addition, they also signal to cells via mechanotransduction pathways to control cell …
Understanding chronic venous disease: a critical overview of its pathophysiology and medical management
MA Ortega, O Fraile-Martínez… - Journal of clinical …, 2021 - mdpi.com
Chronic venous disease (CVD) is a multifactorial condition affecting an important
percentage of the global population. It ranges from mild clinical signs, such as …
percentage of the global population. It ranges from mild clinical signs, such as …
Vascular mechanobiology: homeostasis, adaptation, and disease
JD Humphrey, MA Schwartz - Annual review of biomedical …, 2021 - annualreviews.org
Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …
Fluid shear stress sensing by the endothelial layer
E Roux, P Bougaran, P Dufourcq… - Frontiers in physiology, 2020 - frontiersin.org
Blood flow produces mechanical frictional forces, parallel to the blood flow exerted on the
endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is …
endothelial wall of the vessel, the so-called wall shear stress (WSS). WSS sensing is …
Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes
C Souilhol, J Serbanovic-Canic, M Fragiadaki… - Nature Reviews …, 2020 - nature.com
Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …
vascular function. Branches and bends of arteries are exposed to complex blood flow …
Organotypic vasculature: from descriptive heterogeneity to functional pathophysiology
HG Augustin, GY Koh - Science, 2017 - science.org
BACKGROUND Each organ in the human body has its own capillary bed to carry out its
distinctive and versatile functions in response to dynamically changing systemic and local …
distinctive and versatile functions in response to dynamically changing systemic and local …
Wall shear stress and its role in atherosclerosis
M Zhou, Y Yu, R Chen, X Liu, Y Hu, Z Ma… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis (AS) is the major form of cardiovascular disease and the leading cause of
morbidity and mortality in countries around the world. Atherosclerosis combines the …
morbidity and mortality in countries around the world. Atherosclerosis combines the …