Designed proteins assemble antibodies into modular nanocages
INTRODUCTION Antibodies that bind tightly to targets of interest play central roles in
biological research and medicine. Clusters of antibodies, typically generated by fusing …
biological research and medicine. Clusters of antibodies, typically generated by fusing …
Computational design of mechanically coupled axle-rotor protein assemblies
Natural molecular machines contain protein components that undergo motion relative to
each other. Designing such mechanically constrained nanoscale protein architectures with …
each other. Designing such mechanically constrained nanoscale protein architectures with …
Physics-based computational protein design: an update
D Mignon, K Druart, E Michael, V Opuu… - The Journal of …, 2020 - ACS Publications
We describe methods for physics-based protein design and some recent applications from
our work. We present the physical interpretation of a MC simulation in sequence space and …
our work. We present the physical interpretation of a MC simulation in sequence space and …
The art of engineering biomimetic cellular microenvironments
RC Bretherton, CA DeForest - ACS biomaterials science & …, 2021 - ACS Publications
Cells and their surrounding microenvironment exist in dynamic reciprocity, where
bidirectional feedback and feedforward crosstalk drives essential processes in development …
bidirectional feedback and feedforward crosstalk drives essential processes in development …
De novo protein design using the blueprint builder in Rosetta
While native proteins cover diverse structural spaces and achieve various biological events,
not many of them can directly serve human needs. One reason is that the native proteins …
not many of them can directly serve human needs. One reason is that the native proteins …
Repeat proteins: Designing new shapes and functions for solenoid folds
F Gidley, F Parmeggiani - Current Opinion in Structural Biology, 2021 - Elsevier
Highlights•The structure of repeat protein solenoids allows design of novel modular
proteins.•Different types of repeats can be combined into large architectures.•Sequence …
proteins.•Different types of repeats can be combined into large architectures.•Sequence …
Computational design of nanoscale rotational mechanics in de novo protein assemblies
Natural nanomachines like the F1/F0-ATPase contain protein components that undergo
rotation relative to each other. Designing such mechanically constrained nanoscale protein …
rotation relative to each other. Designing such mechanically constrained nanoscale protein …
Knowledge-Based Unfolded State Model for Protein Design
V Opuu, D Mignon, T Simonson - Computational Peptide Science: Methods …, 2021 - Springer
The design of proteins and miniproteins is an important challenge. Designed variants should
be stable, meaning the folded/unfolded free energy difference should be large enough …
be stable, meaning the folded/unfolded free energy difference should be large enough …