The pathogenesis of tuberculous meningitis

AG Davis, UK Rohlwink, A Proust… - Journal of leukocyte …, 2019 - academic.oup.com
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …

Vaccines and dementia: part I. Non-specific immune boosting with BCG: history, ligands, and receptors

CL Greenblatt, R Lathe - Journal of Alzheimer's Disease, 2024 - content.iospress.com
Abstract Vaccines such as Bacille Calmette–Guérin (BCG) can apparently defer dementia
onset with an efficacy better than all drugs known to date, as initially reported by Gofrit et …

Cognitive function associated with gut microbial abundance in sucrose and S-adenosyl-L-methionine (SAMe) metabolic pathways

S Jeong, LK Huang, MJ Tsai, YT Liao… - Journal of …, 2022 - content.iospress.com
Background: Differential abundance of gut microbiota has found to be associated with
Alzheimer's disease (AD). However, the relative abundance of gut microbiota between …

[HTML][HTML] Potential of Neuroinflammation-Modulating Strategies in Tuberculous Meningitis: Targeting Microglia

HJ Lu, D Guo, QQ Wei - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Tuberculous meningitis (TBM) is the most severe complication of tuberculosis (TB) and is
associated with high rates of disability and mortality. Mycobacterium tuberculosis (M. tb), the …

Microglia are crucial regulators of neuro-immunity during central nervous system tuberculosis

JP Spanos, NJ Hsu, M Jacobs - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Mycobacterium tuberculosis (M. tuberculosis) infection of the central nervous system (CNS)
is the most devastating manifestation of tuberculosis (TB), with both high mortality and …

Mycobacterium tuberculosis infection of the 'non‐classical immune cell'

PJ Randall, NJ Hsu, V Quesniaux… - Immunology and cell …, 2015 - Wiley Online Library
Mycobacterium tuberculosis can infect 'non‐classical immune cells', which comprise a
significant constituency of cells that reside outside of those defined as 'classical immune …

TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis

NM Francisco, NJ Hsu, R Keeton, P Randall… - Journal of …, 2015 - Springer
Background Tuberculosis (TB) affects one third of the global population, and TB of the
central nervous system (CNS-TB) is the most severe form of tuberculosis which often …

Next-Gen Dual Transcriptomics for Adult Extrapulmonary Tuberculosis Biomarkers and Host–Pathogen Interplay in Human Cells: A Strategic Review

M Nesakumar, EH Luke, U Vetrivel - Indian Journal of Microbiology, 2024 - Springer
Tuberculosis (TB) is a major public health concern that results in significant morbidity and
mortality, particularly in middle-to low-income countries. Extra-pulmonary tuberculosis …

Gliosis, misfolded protein aggregation, and neuronal loss in a guinea pig model of pulmonary tuberculosis

AS Latham, CE Geer, DF Ackart, IK Anderson… - Frontiers in …, 2023 - frontiersin.org
Tuberculosis, caused by Mycobacterium tuberculosis infection, is an ongoing epidemic with
an estimated ten million active cases of the disease worldwide. Pulmonary tuberculosis is …

Interactions between CNS and immune cells in tuberculous meningitis

Q Ma, J Chen, X Kong, Y Zeng, Z Chen, H Liu… - Frontiers in …, 2024 - frontiersin.org
The central nervous system (CNS) harbors its own special immune system composed of
microglia in the parenchyma, CNS-associated macrophages (CAMs), dendritic cells …