Targeting the tumor biophysical microenvironment to reduce resistance to immunotherapy

T Zhang, Y Jia, Y Yu, B Zhang, F Xu, H Guo - Advanced drug delivery …, 2022 - Elsevier
Immunotherapy based on immune checkpoint inhibitors has evolved into a new pillar of
cancer treatment in clinics, but dealing with treatment resistance (either primary or acquired) …

Liver fibrosis assessment: MR and US elastography

A Ozturk, MC Olson, AE Samir, SK Venkatesh - Abdominal Radiology, 2022 - Springer
Elastography has emerged as a preferred non-invasive imaging technique for the clinical
assessment of liver fibrosis. Elastography methods provide liver stiffness measurement …

Randomised clinical trial: semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non‐alcoholic fatty liver disease assessed by …

A Flint, G Andersen, P Hockings… - Alimentary …, 2021 - Wiley Online Library
Background Glucagon‐like peptide‐1 receptor agonists may be a treatment option in
patients with non‐alcoholic fatty liver disease (NAFLD). Aims To investigate the effects of …

[HTML][HTML] Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease

A Campos-Murguía, A Ruiz-Margáin… - World journal of …, 2020 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is among the most frequent etiologies of cirrhosis
worldwide, and it is associated with features of metabolic syndrome; the key factor …

US shear-wave elastography dispersion for characterization of chronic liver disease

X Zhang, R Zheng, J Jin, J Wang, T Zhang, J Zeng - Radiology, 2022 - pubs.rsna.org
Background Little is known about the benefits of the use of dispersion slope (DS) as a
viscosity-related parameter derived from two-dimensional (2D) shear-wave elastography …

[HTML][HTML] An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography

J Liang, J Ampuero, H Niu, K Imajo, M Noureddin… - Journal of …, 2023 - Elsevier
Background & Aims We conducted an individual patient data meta-analysis to establish
stiffness cut-off values for magnetic resonance elastography (MRE) in staging liver fibrosis …

Multiparametric MRI in patients with nonalcoholic fatty liver disease

JJ Schaapman, ME Tushuizen… - Journal of Magnetic …, 2021 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in the
world, affecting more than 25% of the adult population. NAFLD covers a spectrum including …

Liver fibrosis imaging: A clinical review of ultrasound and magnetic resonance elastography

YN Zhang, KJ Fowler, A Ozturk, CK Potu… - Journal of Magnetic …, 2020 - Wiley Online Library
Liver fibrosis is a histological hallmark of most chronic liver diseases, which can progress to
cirrhosis and liver failure, and predisposes to hepatocellular carcinoma. Accurate diagnosis …

Mapping heterogenous anisotropic tissue mechanical properties with transverse isotropic nonlinear inversion MR elastography

M McGarry, E Van Houten, D Sowinski, D Jyoti… - Medical image …, 2022 - Elsevier
The white matter tracts of brain tissue consist of highly-aligned, myelinated fibers; white
matter is structurally anisotropic and is expected to exhibit anisotropic mechanical behavior …

A FAPα-activated MRI nanoprobe for precise grading diagnosis of clinical liver fibrosis

J Gao, Y Wang, X Meng, X Wang, F Han, H Xing… - Nature …, 2024 - nature.com
Molecular imaging holds the potential for noninvasive and accurate grading of liver fibrosis.
It is limited by the lack of biomarkers that strongly correlate with liver fibrosis grade. Here, we …