Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
Fluid biomarkers for synaptic dysfunction and loss
E Camporesi, J Nilsson, A Brinkmalm… - Biomarker …, 2020 - journals.sagepub.com
Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …
neurons and stored for memory formation. Synaptic degeneration is a global and early …
Parkinson's disease drug therapies in the clinical trial pipeline: 2020
K McFarthing, S Buff, G Rafaloff… - Journal of …, 2020 - content.iospress.com
Background: The majority of current pharmacological treatments for Parkinson's disease
(PD) were approved for clinical use in the second half of the last century and they only …
(PD) were approved for clinical use in the second half of the last century and they only …
α-Synuclein oligomers induce glutamate release from astrocytes and excessive extrasynaptic NMDAR activity in neurons, thus contributing to synapse loss
Synaptic and neuronal loss are major neuropathological characteristics of Parkinson's
disease. Misfolded protein aggregates in the form of Lewy bodies, comprised mainly of α …
disease. Misfolded protein aggregates in the form of Lewy bodies, comprised mainly of α …
Defining the riddle in order to solve it: there is more than one “Parkinson's disease”
Background More than 200 years after James Parkinsondescribed a clinical syndrome
based on his astute observations, Parkinson's disease (PD) has evolved into a complex …
based on his astute observations, Parkinson's disease (PD) has evolved into a complex …
Curcumin nanoformulations to combat aging-related diseases
M Mahjoob, U Stochaj - Ageing Research Reviews, 2021 - Elsevier
Aging increases the susceptibility to a diverse set of diseases and disorders, including
neurodegeneration, cancer, diabetes, and arthritis. Natural compounds are currently being …
neurodegeneration, cancer, diabetes, and arthritis. Natural compounds are currently being …
α‐Synuclein Radiotracer Development and In Vivo Imaging: Recent Advancements and New Perspectives
OM Alzghool, G van Dongen… - Movement …, 2022 - Wiley Online Library
ABSTRACT α‐Synucleinopathies including idiopathic Parkinson's disease, dementia with
Lewy bodies and multiple systems atrophy share overlapping symptoms and pathological …
Lewy bodies and multiple systems atrophy share overlapping symptoms and pathological …
Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
Neuroprotective function of rasagiline and selegiline, inhibitors of type B monoamine oxidase, and role of monoamine oxidases in synucleinopathies
M Naoi, W Maruyama, M Shamoto-Nagai - International Journal of …, 2022 - mdpi.com
Synucleinopathies are a group of neurodegenerative disorders caused by the accumulation
of toxic species of α-synuclein. The common clinical features are chronic progressive …
of toxic species of α-synuclein. The common clinical features are chronic progressive …
Research Priorities on the Role of α‐Synuclein in Parkinson's Disease Pathogenesis
Various forms of Parkinson's disease, including its common sporadic form, are characterized
by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of …
by prominent α‐synuclein (αSyn) aggregation in affected brain regions. However, the role of …