Advances in the clinical management of uveal melanoma
Melanomas arising in the uveal tract of the eye are a rare form of the disease with a biology
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …
The journey from melanocytes to melanoma
PP Centeno, V Pavet, R Marais - Nature Reviews Cancer, 2023 - nature.com
Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …
[HTML][HTML] Metastatic uveal melanoma: The final frontier
ES Rantala, MM Hernberg, S Piperno-Neumann… - Progress in Retinal and …, 2022 - Elsevier
Abstract Treatment of primary intraocular uveal melanoma has developed considerably, its
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …
[HTML][HTML] Insufficient sun exposure has become a real public health problem
L Alfredsson, BK Armstrong, DA Butterfield… - International Journal of …, 2020 - mdpi.com
This article aims to alert the medical community and public health authorities to
accumulating evidence on health benefits from sun exposure, which suggests that …
accumulating evidence on health benefits from sun exposure, which suggests that …
[HTML][HTML] MITF in normal melanocytes, cutaneous and uveal melanoma: a delicate balance
MC Gelmi, LE Houtzagers, T Strub, I Krossa… - International journal of …, 2022 - mdpi.com
Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …
melanogenesis and melanocyte development. Although it has been studied extensively in …
Comparative genomics provides etiologic and biological insight into melanoma subtypes
Melanoma is a cancer of melanocytes, with multiple subtypes based on body site location.
Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal …
Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal …
[HTML][HTML] The PEMDAC phase 2 study of pembrolizumab and entinostat in patients with metastatic uveal melanoma
Preclinical studies have suggested that epigenetic therapy could enhance immunogenicity
of cancer cells. We report the results of the PEMDAC phase 2 clinical trial (n= 29; …
of cancer cells. We report the results of the PEMDAC phase 2 clinical trial (n= 29; …
[HTML][HTML] Benefits of zebrafish xenograft models in cancer research
X Chen, Y Li, T Yao, R Jia - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
As a promising in vivo tool for cancer research, zebrafish have been widely applied in
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …
[HTML][HTML] Future perspectives of uveal melanoma blood based biomarkers
Uveal melanoma (UM) is the most common primary intraocular malignancy affecting adults.
Despite successful local treatment of the primary tumour, metastatic disease develops in up …
Despite successful local treatment of the primary tumour, metastatic disease develops in up …
[HTML][HTML] Conjunctival melanoma: New insights in tumour genetics and immunology, leading to new therapeutic options
NJ Brouwer, RM Verdijk, S Heegaard… - Progress in Retinal and …, 2022 - Elsevier
Recent developments in oncology have led to a better molecular and cellular understanding
of cancer, and the introduction of novel therapies. Conjunctival melanoma (CoM) is a rare …
of cancer, and the introduction of novel therapies. Conjunctival melanoma (CoM) is a rare …