Current methods used for measuring amino acid side-chain reactivity lack the throughput
needed to screen large chemical libraries for interactions across the proteome. Here we …

Breast cancer became the most diagnosed cancer in the world in 2020. Chemotherapy is
still the leading clinical strategy in breast cancer treatment, followed by hormone therapy …

Covalent protein kinase inhibitors exploit currently noncatalytic cysteines in the adenosine
5′-triphosphate (ATP)-binding site via electrophiles directly appended to a reversible …

Abstract The Src Family Kinases (SFKs) are pivotal regulators of cellular signal transduction
and highly sought-after targets in drug discovery. Their actions within cells are controlled by …

Alzheimer's disease (AD) is a brain disease with a peculiarity of multiformity and an
insidious onset. Multiple-target drugs, especially Chinese traditional medicine, have …

Src is a protein tyrosine kinase commonly activated downstream of transmembrane
receptors and plays key roles in cell growth, migration, and survival signaling pathways. In …

The recent clinical and commercial success of covalent drugs has prompted a renewed
interest in covalent inhibitors as therapeutic agents. With this has come an increased …

Allostery plays a primary role in regulating protein activity, making it an important
mechanism in human disease and drug discovery. Identifying allosteric regulatory sites to …

Inhibition of c-Src is considered one of the most studied approaches to cancer treatment,
with several heterocyclic compounds approved during the last 15 years as …

Network pharmacology was used to illuminate the targets and pathways of polybrominated
diphenyl ethers (PBDEs) causing thyroid dysfunction. A protein‐protein interaction (PPI) …