Ethanol metabolism plays an essential role in how the body perceives and experiences
alcohol consumption, and evidence suggests that modulation of ethanol metabolism can …

The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …

Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied
in the 1940s, but then research interest in this compound waned. However, in the last two …

Alcohol consumption dates back to the Neolithic period, and alcohol dependence
contributes substantially to the current global burden of disease. Despite this, optimal …

Alcohol abuse and alcoholism incur a heavy socioeconomic cost in many countries. Both
genetic and environmental factors contribute to variation in the inebriating effects of alcohol …

The ALDH2* 2 gene encoding the inactive variant form of mitochondrial aldehyde
dehydrogenase (ALDH2) protects nearly all carriers of this gene from alcoholism. Inhibition …

Ethanol-induced behavioral sensitization (EBS) was first described in 1980, approximately
10 years after the phenomenon was described for psychostimulants. Ethanol acts on γ …

Aldehyde dehydrogenase 2 (ALDH2) deficiency causes" Asian flush syndrome," presenting
as alcohol-induced facial flushing, tachycardia, nausea, and headaches. One of the most …

This review analyzes literature that describes the behavioral effects of 2 metabolites of
ethanol (EtOH): acetaldehyde and salsolinol (a condensation product of acetaldehyde and …

Background: Alcohol use disorders (abuse and dependence, AUD) are multifactorial
phenomena, depending on the interplay of environmental and genetic variables. Method …