Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

Fungal endocarditis: pathophysiology, epidemiology, clinical presentation, diagnosis, and management

GR Thompson III, JD Jenks, JW Baddley… - Clinical microbiology …, 2023 - Am Soc Microbiol
Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated
with high morbidity and mortality (> 70%), and presents numerous challenges during clinical …

Pulmonary aspergillosis: diagnosis and treatment

F Lamoth, T Calandra - European Respiratory Review, 2022 - Eur Respiratory Soc
Aspergillus species are the most frequent cause of fungal infections of the lungs with a
broad spectrum of clinical presentations including invasive pulmonary aspergillosis (IPA) …

Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent Public …

A Langfeldt, JAW Gold, T Chiller - Current Clinical Microbiology Reports, 2022 - Springer
Abstract Purpose of Review For this review, we use a One Health approach to examine two
globally emerging public health threats related to antifungal drug resistance: triazole …

Potential airborne human pathogens: A relevant inhabitant in built environments but not considered in indoor air quality standards

E Carrazana, T Ruiz-Gil, S Fujiyoshi, D Tanaka… - Science of the Total …, 2023 - Elsevier
Potential airborne human pathogens (PAHPs) may be a relevant component of the air
microbiome in built environments. Despite that PAHPs can cause infections, particularly in …

Ibrexafungerp, a novel triterpenoid antifungal in development for the treatment of mold infections

DA Angulo, B Alexander, R Rautemaa-Richardson… - Journal of Fungi, 2022 - mdpi.com
Molds are ubiquitous in the environment, and immunocompromised patients are at
substantial risk of morbidity and mortality due to their underlying disease and the resistance …

Addressing microbial resistance worldwide: challenges over controlling life-threatening fungal infections

L Martins-Santana, CP Rezende, A Rossi… - Pathogens, 2023 - mdpi.com
Fungal infections are a serious global concern because of their ability to spread and
colonize host tissues in immunocompromised individuals. Such infections have been …

COVID-19-associated fungal infections: an urgent need for alternative therapeutic approach?

M Domán, K Bányai - Frontiers in Microbiology, 2022 - frontiersin.org
Secondary fungal infections may complicate the clinical course of patients affected by viral
respiratory diseases, especially those admitted to intensive care unit. Hospitalized COVID …

Drug repositioning with GraphSAGE and clustering constraints based on drug and disease networks

Y Zhang, X Lei, Y Pan, FX Wu - Frontiers in Pharmacology, 2022 - frontiersin.org
The understanding of therapeutic properties is important in drug repositioning and drug
discovery. However, chemical or clinical trials are expensive and inefficient to characterize …

Cyclic peptides with antifungal properties derived from bacteria, fungi, plants, and synthetic sources

NM Helmy, K Parang - Pharmaceuticals, 2023 - mdpi.com
Fungal infections remain a significant concern for human health. The emergence of
microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic …