Immune responses to human fungal pathogens and therapeutic prospects
MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …
Fungal endocarditis: pathophysiology, epidemiology, clinical presentation, diagnosis, and management
GR Thompson III, JD Jenks, JW Baddley… - Clinical microbiology …, 2023 - Am Soc Microbiol
Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated
with high morbidity and mortality (> 70%), and presents numerous challenges during clinical …
with high morbidity and mortality (> 70%), and presents numerous challenges during clinical …
Pulmonary aspergillosis: diagnosis and treatment
F Lamoth, T Calandra - European Respiratory Review, 2022 - Eur Respiratory Soc
Aspergillus species are the most frequent cause of fungal infections of the lungs with a
broad spectrum of clinical presentations including invasive pulmonary aspergillosis (IPA) …
broad spectrum of clinical presentations including invasive pulmonary aspergillosis (IPA) …
Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent Public …
A Langfeldt, JAW Gold, T Chiller - Current Clinical Microbiology Reports, 2022 - Springer
Abstract Purpose of Review For this review, we use a One Health approach to examine two
globally emerging public health threats related to antifungal drug resistance: triazole …
globally emerging public health threats related to antifungal drug resistance: triazole …
Potential airborne human pathogens: A relevant inhabitant in built environments but not considered in indoor air quality standards
E Carrazana, T Ruiz-Gil, S Fujiyoshi, D Tanaka… - Science of the Total …, 2023 - Elsevier
Potential airborne human pathogens (PAHPs) may be a relevant component of the air
microbiome in built environments. Despite that PAHPs can cause infections, particularly in …
microbiome in built environments. Despite that PAHPs can cause infections, particularly in …
Ibrexafungerp, a novel triterpenoid antifungal in development for the treatment of mold infections
DA Angulo, B Alexander, R Rautemaa-Richardson… - Journal of Fungi, 2022 - mdpi.com
Molds are ubiquitous in the environment, and immunocompromised patients are at
substantial risk of morbidity and mortality due to their underlying disease and the resistance …
substantial risk of morbidity and mortality due to their underlying disease and the resistance …
Addressing microbial resistance worldwide: challenges over controlling life-threatening fungal infections
Fungal infections are a serious global concern because of their ability to spread and
colonize host tissues in immunocompromised individuals. Such infections have been …
colonize host tissues in immunocompromised individuals. Such infections have been …
COVID-19-associated fungal infections: an urgent need for alternative therapeutic approach?
Secondary fungal infections may complicate the clinical course of patients affected by viral
respiratory diseases, especially those admitted to intensive care unit. Hospitalized COVID …
respiratory diseases, especially those admitted to intensive care unit. Hospitalized COVID …
Drug repositioning with GraphSAGE and clustering constraints based on drug and disease networks
The understanding of therapeutic properties is important in drug repositioning and drug
discovery. However, chemical or clinical trials are expensive and inefficient to characterize …
discovery. However, chemical or clinical trials are expensive and inefficient to characterize …
Cyclic peptides with antifungal properties derived from bacteria, fungi, plants, and synthetic sources
NM Helmy, K Parang - Pharmaceuticals, 2023 - mdpi.com
Fungal infections remain a significant concern for human health. The emergence of
microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic …
microbial resistance, the improper use of antimicrobial drugs, and the need for fewer toxic …