The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

Endothelial cells (ECs) form an extensive network of blood vessels that has numerous
essential functions in the vertebrate body. In addition to their well-established role as a …

Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …

This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …

Human and rodent islets differ substantially in several features, including architecture, cell
composition, gene expression and some aspects of insulin secretion. Mouse pancreatic …

Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

Placental insufficiency is a primary cause of intrauterine growth restriction (IUGR). IUGR
increases the risk of developing type 2 diabetes mellitus (T2DM) throughout life, which …

Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β
cell dysfunction. Excess glucose and lipid impair β cell function in islet cell lines, cultured …

The pancreatic islet is a highly vascularized endocrine micro-organ. The unique architecture
of rodent islets, a so-called core-mantle arrangement seen in two-dimensional images, led …

The islets of Langerhans are highly organized structures that have species-specific, three-
dimensional tissue architecture. Islet architecture is critical for proper hormone secretion in …