Simple Summary This review aims to shed light on the proliferative markers important in the
everyday clinical management of colorectal cancer (CRC), ranging from simple methods of …

Overall survival benefit of total neoadjuvant treatment (TNT) remains unconfirmed. Thus, in
our opinion, the main rationale for using TNT is a planned watch-and-wait (w&w) strategy to …

Background Frequency and predictive factors for a clinical complete response (cCR) in
unselected patients are unclear. Material and methods Two prospective observational …

Goals: To evaluate the role of length of the interval between 5× 5 Gy and surgery. Methods:
PubMed was searched to perform a systematic review. Results: There were 10 studies on 5× …

Preoperative radiotherapy (RT) or chemoradiotherapy (CRT) is often required before rectal
cancer surgery to obtain low local recurrence rates or, in locally advanced tumours, to …

There are 2 types of neoadjuvant radiation regimens accepted as standard for resectable
rectal cancer: short-course (5× 5 Gy) radiation therapy alone with immediate surgery and …

Purpose Inhibition of tumor proliferation rate based on bromodeoxyuridine labelling index
(BrdUrdLI), S-phase fraction (SPF) and MIB-1 labelling index (MIB-1 LI) as an early rectal …

To the Editor—Evans et al1 demonstrated increased rectal cancer downstaging when the
interval between preoperative radiation and surgery had been 8 weeks. The authors …

Background Prognostic value of pretreatment expression of proteins in rectal cancer for
early pathological tumor response (pTR), clinical tumor response (CTR) to preoperative …

Aim To study the prognostic value of clinical and biological features of rectal cancer and
potential gender differences in patients' overall survival (OS), local recurrence-free survival …