S phingolipids constitute a class of lipids defined by their eighteen carbon amino-alcohol
backbones which are synthesized in the ER from nonsphingolipid precursors. Modification …

Biologically active sphingolipids have key roles in the regulation of several fundamental
biological processes that are integral to cancer pathogenesis. Recent significant progress in …

The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases
inflammation and promotes cell survival. No unifying mechanism has yet explained how …

Over the past three decades, extensive research has been able to determine the biologic
functions for the main bioactive sphingolipids, namely ceramide, sphingosine, and …

Events—The cloning of enzymes that clear ceramide such as GCS and CDases (1, 2), the
generation of knock-out mice in acid SMase (13), and the development/discovery of specific …

Recent years have witnessed significant advances in the understanding of the role of
ceramide in apoptosis. This review summarizes these recent findings and discusses insights …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Sphingolipids are comprised of a backbone sphingoid base that may be phosphorylated,
acylated, glycosylated, bridged to various headgroups through phosphodiester linkages, or …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

Ceramidases catalyze hydrolysis of ceramides to generate sphingosine (SPH), which is
phosphorylated to form sphingosine-1-phosphate (S1P). Ceramide, SPH, and S1P are …