Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
Steering and controlling evolution—from bioengineering to fighting pathogens
M Lässig, V Mustonen, A Nourmohammad - Nature Reviews Genetics, 2023 - nature.com
Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …
towards a desired outcome. Applications range from engineering biomolecules and …
[HTML][HTML] SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans
SARS-CoV-2 mRNA vaccines induce robust anti-spike (S) antibody and CD4+ T cell
responses. It is not yet clear whether vaccine-induced follicular helper CD4+ T (T FH) cell …
responses. It is not yet clear whether vaccine-induced follicular helper CD4+ T (T FH) cell …
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
INTRODUCTION The clinical manifestations of COVID-19 vary from asymptomatic infection
to respiratory failure. Severe disease courses are primarily associated with advanced age …
to respiratory failure. Severe disease courses are primarily associated with advanced age …
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19
S Notarbartolo, V Ranzani, A Bandera, P Gruarin… - Science …, 2021 - science.org
To understand how a protective immune response against SARS-CoV-2 develops over time,
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
Next-generation sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease
C Schultheiß, L Paschold, D Simnica, M Mohme… - Immunity, 2020 - cell.com
We profiled adaptive immunity in COVID-19 patients with active infection or after recovery
and created a repository of currently> 14 million B and T cell receptor (BCR and TCR) …
and created a repository of currently> 14 million B and T cell receptor (BCR and TCR) …
[HTML][HTML] SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors
Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting
the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID …
the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID …
Integrating T cell receptor sequences and transcriptional profiles by clonotype neighbor graph analysis (CoNGA)
Links between T cell clonotypes, as defined by T cell receptor (TCR) sequences, and
phenotype, as reflected in gene expression (GEX) profiles, surface protein expression and …
phenotype, as reflected in gene expression (GEX) profiles, surface protein expression and …
Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data
Recent advances in single-cell immune profiling have enabled the simultaneous
measurement of transcriptome and T cell receptor (TCR) sequences, offering great potential …
measurement of transcriptome and T cell receptor (TCR) sequences, offering great potential …
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key
role in the adaptive antiviral immune response by killing infected cells and facilitating the …
role in the adaptive antiviral immune response by killing infected cells and facilitating the …