The presence of supernumerary chromosomes is the only abnormality shared by all patients
diagnosed with high-hyperdiploid B cell acute lymphoblastic leukemia (HD-ALL). Despite …

Drug resistance is the major determinant for metastatic disease and fatalities, across all
cancers. Depending on the tissue of origin and the therapeutic course, a variety of biological …

Kinesin spindle protein (Eg5) has been widely studied, as an important target for developing
chemotherapy drugs, due to its essential role in mitotic spindle formation in mitosis. In this …

Centrosome amplification (CA), an abnormal increase in the number of centrosomes in the
cell, is a recurrent phenomenon in lung and other malignancies. Although CA contributes to …

Chemotherapy induced polyploidy is a mechanism of inherited drug resistance resulting in
an aggressive disease course in cancer patients. Alisertib, an Aurora Kinase A ATP site …