Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours

C Horbinski, T Berger, RJ Packer, PY Wen - Nature Reviews Neurology, 2022 - nature.com
A new edition of the WHO classification of tumours of the CNS was published in 2021.
Although the previous edition of this classification was published just 5 years earlier, in …

Medulloblastoma in the age of molecular subgroups: a review: JNSPG 75th Anniversary Invited Review Article

K Juraschka, MD Taylor - Journal of Neurosurgery: Pediatrics, 2019 - thejns.org
Medulloblastoma is the most common pediatric malignant brain tumor. Advances in
molecular profiling have uncovered significant heterogeneity among medulloblastomas and …

Medulloblastoma

PA Northcott, GW Robinson, CP Kratz… - Nature reviews Disease …, 2019 - nature.com
Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Childhood brain tumors: current management, biological insights, and future directions: JNSPG 75th Anniversary Invited Review Article

IF Pollack, S Agnihotri, A Broniscer - Journal of Neurosurgery: Pediatrics, 2019 - thejns.org
Brain tumors are the most common solid tumors in children, and, unfortunately, many
subtypes continue to have a suboptimal long-term outcome. During the last several years …

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 …

M Kool, A Korshunov, M Remke, DTW Jones… - Acta …, 2012 - Springer
Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies
from several groups around the world demonstrated that medulloblastoma is not one …

Outcomes for children and adolescents with cancer: challenges for the twenty-first century

MA Smith, NL Seibel, SF Altekruse, LAG Ries… - Journal of clinical …, 2010 - ascopubs.org
Purpose This report provides an overview of current childhood cancer statistics to facilitate
analysis of the impact of past research discoveries on outcome and provide essential …

Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location

M Karremann, GH Gielen, M Hoffmann… - Neuro …, 2018 - academic.oup.com
Background The novel entity of “diffuse midline glioma, H3 K27M-mutant” has been defined
in the 2016 revision of the World Health Organization (WHO) classification of tumors of the …

Medulloblastoma

NE Millard, KC De Braganca - Journal of child neurology, 2016 - journals.sagepub.com
Medulloblastoma accounts for nearly 10% of all childhood brain tumors. These tumors occur
exclusively in the posterior fossa and have the potential for leptomeningeal spread …

[HTML][HTML] METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma

ZW Zhang, X Teng, F Zhao, C Ma, J Zhang, LF Xiao… - Cell Reports, 2022 - cell.com
Summary SHH subgroup medulloblastoma (SHH-MB) is one of the most common malignant
pediatric tumors that arises in the cerebellum. Previously, we showed that RNA m 6 A …

Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma

JT Huse, EC Holland - Nature reviews cancer, 2010 - nature.com
Malignant brain tumours continue to be the cause of a disproportionate level of morbidity
and mortality across a wide range of individuals. The most common variants in the adult and …