[HTML][HTML] Atorvastatin ameliorated myocardial fibrosis in db/db mice by inhibiting oxidative stress and modulating macrophage polarization
XM Song, MN Zhao, GZ Li, N Li, T Wang… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND People with diabetes mellitus (DM) suffer from multiple chronic
complications due to sustained hyperglycemia, especially diabetic cardiomyopathy (DCM) …
complications due to sustained hyperglycemia, especially diabetic cardiomyopathy (DCM) …
MiR-155 dysregulation is associated with the augmentation of ROS/p53 axis of fibrosis in thioacetamide-induced hepatotoxicity and is protected by resveratrol
AF Dawood, S Al Humayed, MA Momenah… - Diagnostics, 2022 - mdpi.com
Liver fibrosis is a hallmark of thioacetamide (TAA) intoxications. MicroRNAs (miRs), such as
miR-155, have been implied in the pathogenesis of liver disease, and regulated by the …
miR-155, have been implied in the pathogenesis of liver disease, and regulated by the …
Metformin suppresses thioacetamide-induced chronic kidney disease in association with the upregulation of AMPK and downregulation of oxidative stress and …
MY Alshahrani, HA Ebrahim, SM Alqahtani… - Molecules, 2023 - mdpi.com
Toxic chemicals such as carbon tetrachloride and thioacetamide (TAA) are reported to
induce hepato-nephrotoxicity. The potential protective outcome of the antidiabetic and …
induce hepato-nephrotoxicity. The potential protective outcome of the antidiabetic and …
The latest emerging drugs for the treatment of diabetic cardiomyopathy
M Li, L Liu, C Zhang, L Deng, Y Zhong… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus
involving multiple pathophysiologic mechanisms. In addition to hypoglycemic agents …
involving multiple pathophysiologic mechanisms. In addition to hypoglycemic agents …
The Antidiabetic Drug Metformin Attenuated Depressive and Anxiety-like Behaviors and Oxidative Stress in the Brain in a Rodent Model of Inflammation Induced by …
FSH Kakhki, A Asghari, Z Bardaghi… - … Metabolic & Immune …, 2024 - benthamdirect.com
Background: Inflammation is considered to be a link between diabetes and central nervous
system (CNS) disorders, including depression and anxiety. Metformin is suggested to have …
system (CNS) disorders, including depression and anxiety. Metformin is suggested to have …
AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn2B/− spinal muscular atrophy mice
SJ Brown, D Šoltić, SA Synowsky… - Human Molecular …, 2023 - academic.oup.com
Structural, functional and molecular cardiac defects have been reported in spinal muscular
atrophy (SMA) patients and mouse models. Previous quantitative proteomics analyses …
atrophy (SMA) patients and mouse models. Previous quantitative proteomics analyses …
Nitrative modification of caveolin-3: A novel mechanism of cardiac insulin resistance and a potential therapeutic target against ischemic heart failure in prediabetic …
Background: Myocardial insulin resistance is a hallmark of diabetic cardiac injury. However,
the underlying molecular mechanisms remain unclear. Recent studies demonstrate that the …
the underlying molecular mechanisms remain unclear. Recent studies demonstrate that the …
Effects of dapagliflozin on myocardial gene expression in BTBR mice with type 2 diabetes
M Ryaboshapkina, R Ye, Y Ye, Y Birnbaum - Cardiovascular Drugs and …, 2023 - Springer
Background Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, is approved
for the treatment of type 2 diabetes, heart failure, and chronic kidney disease. DAPA-HF and …
for the treatment of type 2 diabetes, heart failure, and chronic kidney disease. DAPA-HF and …
Lower Extremity Arterial Disease in Type 2 Diabetes Mellitus: Metformin Inhibits Femoral Artery Ultrastructural Alterations as well as Vascular Tissue Levels of AGEs …
Lower extremity arterial disease (LEAD) is a major risk factor for amputation in diabetic
patients. The advanced glycation end products (AGEs)/endothelin-1 (ET-1)/nitric oxide …
patients. The advanced glycation end products (AGEs)/endothelin-1 (ET-1)/nitric oxide …
Partial synthetic PPARƳ derivative ameliorates aorta injury in experimental diabetic rats mediated by activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR expression
Type 2 diabetes mellitus (T2D) is a world wild health care issue marked by insulin
resistance, a risk factor for the metabolic disorder that exaggerates endothelial dysfunction …
resistance, a risk factor for the metabolic disorder that exaggerates endothelial dysfunction …