Part 10: special circumstances of resuscitation: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular …

EJ Lavonas, IR Drennan, A Gabrielli, AC Heffner… - Circulation, 2015 - Am Heart Assoc
Guidelines Update for Cardiopulmonary Resuscitation (CPR) and Emergency
Cardiovascular Care (ECC) addresses cardiac arrest in situations that require special …

Local anesthetic systemic toxicity: a narrative literature review and clinical update on prevention, diagnosis, and management

M Gitman, MR Fettiplace, GL Weinberg… - Plastic and …, 2019 - journals.lww.com
Background: The objective of this narrative review of local anesthetic systemic toxicity is to
provide an update on its prevention, diagnosis, and management. Methods: The authors …

The mechanisms underlying lipid resuscitation therapy

MR Fettiplace, G Weinberg - Regional Anesthesia & Pain Medicine, 2018 - rapm.bmj.com
The experimental use of lipid emulsion for local anesthetic toxicity was originally identified in
1998. It was then translated to clinical practice in 2006 and expanded to drugs other than …

Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion

MR Fettiplace, K Lis, R Ripper, K Kowal… - Journal of Controlled …, 2015 - Elsevier
Triglyceride micro-emulsions such as Intralipid® have been used to reverse cardiac toxicity
induced by a number of drugs but reservations about their broad-spectrum applicability …

Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity

LCG Hoegberg, TC Bania, V Lavergne, B Bailey… - Clinical …, 2016 - Taylor & Francis
Background: Following national and regional recommendations, intravenous lipid emulsion
(ILE) has become established in clinical practice as a treatment for acute local anesthetic …

Confusion about infusion: rational volume limits for intravenous lipid emulsion during treatment of oral overdoses

MR Fettiplace, BS Akpa, I Rubinstein… - Annals of emergency …, 2015 - annemergmed.com
After the initial report of treatment of bupropion and lamotrigine overdose by intravenous
lipid emulsion, 1 additional case reports have asserted the usefulness of lipid emulsion for …

Past, present, and future of lipid resuscitation therapy

MR Fettiplace, G Weinberg - Journal of Parenteral and Enteral …, 2015 - Wiley Online Library
Lipid resuscitation therapy was identified in 1998 as an effective treatment for local
anesthetic systemic toxicity in an animal model. Since the original observation, the field has …

Intravenous lipid emulsion as an adjuvant therapy of acute clozapine poisoning

FM Elgazzar, MS Elgohary… - Human & …, 2021 - journals.sagepub.com
Introduction: Clozapine is a frequently prescribed atypical antipsychotic drug. Various case
reports documented the successful recovery of acute antipsychotics toxicity in association …

[HTML][HTML] Should we consider the infusion of lipid emulsion in the resuscitation of poisoned patients?

G Cave, MG Harvey - Critical Care, 2014 - Springer
The use of intravenous lipid emulsions (ILEs) as antidote in local anaesthetic systemic
toxicity has gained widespread support following convincing data from animal models, and …

Lipid emulsion for xenobiotic overdose: PRO

MR Fettiplace, G Weinberg - British journal of clinical …, 2023 - Wiley Online Library
Infusion of lipid emulsion for drug overdose arose as a treatment for local anaesthetic
systemic toxicity (LAST) initially based on laboratory results in animal models with the …