Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
The role of iron in brain ageing and neurodegenerative disorders
In the CNS, iron in several proteins is involved in many important processes such as oxygen
transportation, oxidative phosphorylation, myelin production, and the synthesis and …
transportation, oxidative phosphorylation, myelin production, and the synthesis and …
[HTML][HTML] Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study
Quantitative susceptibility mapping (QSM) is a novel technique which allows determining the
bulk magnetic susceptibility distribution of tissue in vivo from gradient echo magnetic …
bulk magnetic susceptibility distribution of tissue in vivo from gradient echo magnetic …
Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan
W Li, B Wu, A Batrachenko, V Bancroft‐Wu… - Human brain …, 2014 - Wiley Online Library
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination and …
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination and …
[HTML][HTML] Quantifying inter-individual anatomical variability in the subcortex using 7 T structural MRI
Functional magnetic resonance imaging (MRI) data are usually registered into standard
anatomical space. However, standard atlases, such as LPBA40, the Harvard–Oxford atlas …
anatomical space. However, standard atlases, such as LPBA40, the Harvard–Oxford atlas …
Brain iron metabolism dysfunction in Parkinson's disease
H Jiang, J Wang, J Rogers, J Xie - Molecular neurobiology, 2017 - Springer
Dysfunction of iron metabolism, which includes its uptake, storage, and release, plays a key
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …
The role of free radicals in the aging brain and Parkinson's disease: convergence and parallelism
Free radical production and their targeted action on biomolecules have roles in aging and
age-related disorders such as Parkinson's disease (PD). There is an age-associated …
age-related disorders such as Parkinson's disease (PD). There is an age-associated …
Increased iron deposition on brain quantitative susceptibility mapping correlates with decreased cognitive function in Alzheimer's disease
L Du, Z Zhao, A Cui, Y Zhu, L Zhang, J Liu… - ACS chemical …, 2018 - ACS Publications
The excessive accumulation of iron in deep gray structures is an important pathological
characteristic in patients with Alzheimer's disease (AD). Quantitative susceptibility mapping …
characteristic in patients with Alzheimer's disease (AD). Quantitative susceptibility mapping …
Iron levels in the human brain: a post-mortem study of anatomical region differences and age-related changes
P Ramos, A Santos, NR Pinto, R Mendes… - Journal of Trace …, 2014 - Elsevier
The link between brain iron homeostasis and neurodegenerative disease has been the
subject of extensive research. There is increasing evidence of iron accumulation during …
subject of extensive research. There is increasing evidence of iron accumulation during …