Roles of HLA-G in the maternal-fetal immune microenvironment
X Xu, Y Zhou, H Wei - Frontiers in immunology, 2020 - frontiersin.org
During pregnancy, the maternal uterus and fetus form a special microenvironment at the
maternal-fetal interface to support fetal development. Extravillous trophoblasts (EVTs) …
maternal-fetal interface to support fetal development. Extravillous trophoblasts (EVTs) …
HLA-G: at the interface of maternal–fetal tolerance
During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine
mucosa without being rejected by the maternal immune system. Several mechanisms were …
mucosa without being rejected by the maternal immune system. Several mechanisms were …
Controlling natural killer cell responses: integration of signals for activation and inhibition
Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …
in the absence of antigen-specific receptors has been a challenge, but recent work has …
Structure/function of human killer cell immunoglobulin‐like receptors: lessons from polymorphisms, evolution, crystal structures and mutations
KS Campbell, AK Purdy - Immunology, 2011 - Wiley Online Library
Stimulation or tolerance of natural killer (NK) cells is achieved through a cross‐talk of signals
derived from cell surface activating and inhibitory receptors. Killer cell immunoglobulin‐like …
derived from cell surface activating and inhibitory receptors. Killer cell immunoglobulin‐like …
Natural killer cell-produced IFN-γ and TNF-α induce target cell cytolysis through up-regulation of ICAM-1
R Wang, JJ Jaw, NC Stutzman, Z Zou… - Journal of leukocyte …, 2012 - academic.oup.com
ABSTRACT NK cells control tumor and virus-infected cells through releasing cytotoxic
granules and proinflammatory cytokines. IFN-γ and TNF-α secretions and cytotoxicity are …
granules and proinflammatory cytokines. IFN-γ and TNF-α secretions and cytotoxicity are …
Research progress on NK cell receptors and their signaling pathways
Y Chen, D Lu, A Churov, R Fu - Mediators of Inflammation, 2020 - Wiley Online Library
Natural killer cells (NK cells) play an important role in innate immunity. NK cells recognize
self and nonself depending on the balance of activating receptors and inhibitory receptors …
self and nonself depending on the balance of activating receptors and inhibitory receptors …
The HLA-G cycle provides for both NK tolerance and immunity at the maternal–fetal interface
T Tilburgs, JH Evans, ÂC Crespo… - Proceedings of the …, 2015 - National Acad Sciences
The interaction of noncytotoxic decidual natural killer cells (dNK) and extravillous
trophoblasts (EVT) at the maternal–fetal interface was studied. Confocal microscopy …
trophoblasts (EVT) at the maternal–fetal interface was studied. Confocal microscopy …
KIR2DL4 (CD158d): an activation receptor for HLA-G
S Rajagopalan, EO Long - Frontiers in immunology, 2012 - frontiersin.org
KIR2DL4 is an unusual killer cell immunoglobulin-like receptor (KIR) family member in terms
of its structure, expression, cellular localization, and signaling properties. The most …
of its structure, expression, cellular localization, and signaling properties. The most …
Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling
S Rajagopalan, EO Long - Proceedings of the National …, 2012 - National Acad Sciences
Natural killer (NK) cells, which have an essential role in immune defense, also contribute to
reproductive success. NK cells are abundant at the maternal–fetal interface, where soluble …
reproductive success. NK cells are abundant at the maternal–fetal interface, where soluble …
DNA-PKcs: a targetable protumorigenic protein kinase
E Dylgjeri, KE Knudsen - Cancer Research, 2022 - AACR
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase
that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression …
that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression …