The soil microbial community fulfils various functions, such as nutrient cycling and carbon
(C) sequestration, therefore contributing to maintenance of soil fertility and mitigation of …

The reconstruction and analysis of genome-scale metabolic models constitutes a powerful
systems biology approach, with applications ranging from basic understanding of genotype …

To the Editor—Reconstructing metabolic reaction networks enables the development of
testable hypotheses of an organism's metabolism under different conditions 1. State-of-the …

Genome-scale metabolic models are instrumental in uncovering operating principles of
cellular metabolism, for model-guided re-engineering, and unraveling cross-feeding in …

Abstract The BiGG Models knowledge base (http://bigg. ucsd. edu) is a centralized
repository for high-quality genome-scale metabolic models. For the past 12 years, the …

Life and the genetic code are self-referential and so are autocatalytic networks made of
simpler, small molecules. Several origins of life theories postulate autocatalytic chemical …

Metagenomic sequencing of complete microbial communities has greatly enhanced our
understanding of the taxonomic composition of microbiotas. This has led to breakthrough …

In cell and molecular biology, metabolism is the only system that can be fully simulated at
genome scale. Metabolic systems biology offers powerful abstraction tools to simulate all …

Bacteria are the most abundant cells on Earth. They are generally regarded as ancient, but
due to striking diversity in their metabolic capacities and widespread lateral gene transfer …

Background Cell line-specific, genome-scale metabolic models enable rigorous and
systematic in silico investigation of cellular metabolism. Such models have recently become …