The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It
is comprised of membrane-attached proteoglycans, glycosaminoglycan chains …

Disseminated intravascular coagulation (DIC) has been recognized as a deadly
complication in sepsis, and its early recognition followed by appropriate management of the …

Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …

The vascular endothelial surface is coated by the glycocalyx, a ubiquitous gel‐like layer
composed of a membrane‐binding domain that contains proteoglycans, glycosaminoglycan …

Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute
respiratory distress syndrome (ARDS) being the most severe form of ALI and having a …

One quarter of patients suffering from acute critical illness such as severe trauma, sepsis,
myocardial infarction (MI) or post cardiac arrest syndrome (PCAS) develop severe …

The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans,
secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such …

Hyaluronan (HA) is a ubiquitous glycosaminoglycan of the extracellular matrix. It is present
in the endothelial glycocalyx covering the apical surface of endothelial cells. The endothelial …

Vascular injury has emerged as a complication contributing to morbidity in coronavirus
disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component …

Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …