Apical constriction is a cell shape change that promotes tissue remodeling in a variety of
homeostatic and developmental contexts, including gastrulation in many organisms and …

Tissue size, shape, and organization reflect individual cell behaviors such as proliferation,
shape change, and movement. Evidence suggests that mechanical signals operate in …

Tissue morphogenesis requires coordination of multiple force-producing components.
During dorsal closure in fly embryogenesis, an epidermis opening closes. A tensioned …

Dorsal closure is a key process during Drosophila morphogenesis that models cell sheet
movements in chordates, including neural tube closure, palate formation, and wound …

Dorsal closure, a late-embryogenesis process, consists in the sealing of an epidermal gap
on the dorsal side of the Drosophila embryo. Because of its similarities with wound healing …

Oscillatory morphodynamics provides necessary mechanical cues for many multicellular
processes. Owing to their collective nature, these processes require robustly coordinated …

Throughout development, tissues exhibit dynamic cell deformation, which is characterized
by the integration of cell boundary contraction and/or elongation. Such changes ultimately …

Current efforts in developing treatments for diabetes focus on in vitro generation of functional
β-cells for cell replacement therapies; however, these attempts have only been partly …

Pulsatile actomyosin contractility driving cell shape oscillations is a common feature of
actomyosin networks present in a variety of tissues undergoing morphogenetic processes …

The evolutionarily conserved Crumbs protein is required for epithelial polarity and
morphogenesis. Here we identify a novel role of Crumbs as a negative regulator of …