Liquid biopsy for monitoring of tumor dormancy and early detection of disease recurrence in solid tumors
Cancer is one of the three leading causes of death worldwide. Even after successful therapy
and achieving remission, the risk of relapse often remains. In this context, dormant residual …
and achieving remission, the risk of relapse often remains. In this context, dormant residual …
Parrondo's paradox reveals counterintuitive wins in biology and decision making in society
Parrondo's paradox refers to the paradoxical phenomenon of combining two losing
strategies in a certain manner to obtain a winning outcome. It has been applied to uncover …
strategies in a certain manner to obtain a winning outcome. It has been applied to uncover …
Extending the lifespan of multicellular organisms via periodic and stochastic intercellular competition
Resolution of the intrinsic conflict between the reproduction of single cells and the
homeostasis of a multicellular organism is central to animal biology and has direct impact on …
homeostasis of a multicellular organism is central to animal biology and has direct impact on …
Bridging tumorigenesis and therapy resistance with a non-darwinian and non-lamarckian mechanism of adaptive evolution
Although neo-Darwinian (and less often Lamarckian) dynamics are regularly invoked to
interpret cancer's multifarious molecular profiles, they shine little light on how tumorigenesis …
interpret cancer's multifarious molecular profiles, they shine little light on how tumorigenesis …
From developmental to atavistic bet‐hedging: How cancer cells pervert the exploitation of random single‐cell phenotypic fluctuations
JP Capp, F Thomas - BioEssays, 2022 - Wiley Online Library
Stochastic gene expression plays a leading developmental role through its contribution to
cell differentiation. It is also proposed to promote phenotypic diversification in malignant …
cell differentiation. It is also proposed to promote phenotypic diversification in malignant …
Parrondo's paradox in susceptible-infectious-susceptible dynamics over periodic temporal networks
Many social and biological networks periodically change over time with daily, weekly, and
other cycles. Thus motivated, we formulate and analyze susceptible-infectious-susceptible …
other cycles. Thus motivated, we formulate and analyze susceptible-infectious-susceptible …
Parrondo's effects with aperiodic protocols
In this work, we study the effectiveness of employing archetypal aperiodic sequencing--
namely Fibonacci, Thue-Morse, and Rudin-Saphiro--on the Parrondian effect. From a capital …
namely Fibonacci, Thue-Morse, and Rudin-Saphiro--on the Parrondian effect. From a capital …
[HTML][HTML] Ecology and games in cancer: new insights into the disease
Cancer is a complex, dynamic disease that is under permanent study by basic scientists,
oncologists, pathologists, and other specialists. The different ways by which cancers evolve …
oncologists, pathologists, and other specialists. The different ways by which cancers evolve …
Intercellular competitive growth dynamics with microenvironmental feedback
DM Liu, ZX Wu, JY Guan - Physical Review E, 2023 - APS
Normal life activities between cells rely crucially on the homeostasis of the cellular
microenvironment, but aging and cancer will upset this balance. In this paper we introduce …
microenvironment, but aging and cancer will upset this balance. In this paper we introduce …
An Approach to Cell Motility as a Key Mechanism in Oncology
JI López, IM De la Fuente - Cancers, 2021 - mdpi.com
Motility is an inherent characteristic of living cells manifesting cell migration, a fundamental
mechanism of survival and development. In unicellular organisms, cell migration is needed …
mechanism of survival and development. In unicellular organisms, cell migration is needed …