Liquid biopsy for monitoring of tumor dormancy and early detection of disease recurrence in solid tumors

I Heidrich, B Deitert, S Werner, K Pantel - Cancer and Metastasis Reviews, 2023 - Springer
Cancer is one of the three leading causes of death worldwide. Even after successful therapy
and achieving remission, the risk of relapse often remains. In this context, dormant residual …

Parrondo's paradox reveals counterintuitive wins in biology and decision making in society

T Wen, KH Cheong - Physics of Life Reviews, 2024 - Elsevier
Parrondo's paradox refers to the paradoxical phenomenon of combining two losing
strategies in a certain manner to obtain a winning outcome. It has been applied to uncover …

Extending the lifespan of multicellular organisms via periodic and stochastic intercellular competition

T Wen, KH Cheong, JW Lai, JM Koh, EV Koonin - Physical Review Letters, 2022 - APS
Resolution of the intrinsic conflict between the reproduction of single cells and the
homeostasis of a multicellular organism is central to animal biology and has direct impact on …

Bridging tumorigenesis and therapy resistance with a non-darwinian and non-lamarckian mechanism of adaptive evolution

F Catania, B Ujvari, B Roche, JP Capp… - Frontiers in …, 2021 - frontiersin.org
Although neo-Darwinian (and less often Lamarckian) dynamics are regularly invoked to
interpret cancer's multifarious molecular profiles, they shine little light on how tumorigenesis …

From developmental to atavistic bet‐hedging: How cancer cells pervert the exploitation of random single‐cell phenotypic fluctuations

JP Capp, F Thomas - BioEssays, 2022 - Wiley Online Library
Stochastic gene expression plays a leading developmental role through its contribution to
cell differentiation. It is also proposed to promote phenotypic diversification in malignant …

Parrondo's paradox in susceptible-infectious-susceptible dynamics over periodic temporal networks

MI Sejunti, D Taylor, N Masuda - arXiv preprint arXiv:2406.16787, 2024 - arxiv.org
Many social and biological networks periodically change over time with daily, weekly, and
other cycles. Thus motivated, we formulate and analyze susceptible-infectious-susceptible …

Parrondo's effects with aperiodic protocols

MA Pires, EP Pinto, RN da Silva… - arXiv preprint arXiv …, 2024 - arxiv.org
In this work, we study the effectiveness of employing archetypal aperiodic sequencing--
namely Fibonacci, Thue-Morse, and Rudin-Saphiro--on the Parrondian effect. From a capital …

[HTML][HTML] Ecology and games in cancer: new insights into the disease

C Manini, JI López - Pathologica, 2022 - ncbi.nlm.nih.gov
Cancer is a complex, dynamic disease that is under permanent study by basic scientists,
oncologists, pathologists, and other specialists. The different ways by which cancers evolve …

Intercellular competitive growth dynamics with microenvironmental feedback

DM Liu, ZX Wu, JY Guan - Physical Review E, 2023 - APS
Normal life activities between cells rely crucially on the homeostasis of the cellular
microenvironment, but aging and cancer will upset this balance. In this paper we introduce …

An Approach to Cell Motility as a Key Mechanism in Oncology

JI López, IM De la Fuente - Cancers, 2021 - mdpi.com
Motility is an inherent characteristic of living cells manifesting cell migration, a fundamental
mechanism of survival and development. In unicellular organisms, cell migration is needed …