[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

RNA-binding proteins in tumor progression

H Qin, H Ni, Y Liu, Y Yuan, T Xi, X Li… - Journal of hematology & …, 2020 - Springer
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

S Mohibi, X Chen, J Zhang - Pharmacology & therapeutics, 2019 - Elsevier
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Sensing the scent of death: modulation of microRNAs by curcumin in gastrointestinal cancers

M Ashrafizadeh, A Zarrabi, M Hashemipour… - Pharmacological …, 2020 - Elsevier
Gastrointestinal (GI) cancers with a high incidence rate and adverse complications are
related to severe morbidity and mortality around the world. MicroRNAs (miRs) are potential …

Deciphering STAT3 signaling potential in hepatocellular carcinoma: tumorigenesis, treatment resistance, and pharmacological significance

M Hashemi, E Sabouni, P Rahmanian… - Cellular & molecular …, 2023 - Springer
Hepatocellular carcinoma (HCC) is considered one of the greatest challenges to human life
and is the most common form of liver cancer. Treatment of HCC depends on chemotherapy …

CPEB1 enhances erastin‐induced ferroptosis in gastric cancer cells by suppressing twist1 expression

J Wang, T Wang, Y Zhang, J Liu, J Song, Y Han… - IUBMB …, 2021 - Wiley Online Library
The induction of ferroptosis is considered a new strategy for cancer treatment. Cytoplasmic
polyadenylation element binding protein 1 (CPEB1) is a post‐transcriptional regulatory …

Interferon drives HCV scarring of the epigenome and creates targetable vulnerabilities following viral clearance

RA Hlady, X Zhao, LY El Khoury, A Luna, K Pham… - …, 2022 - Wiley Online Library
Abstract Background and Aims Chronic HCV infection is a leading etiologic driver of
cirrhosis and ultimately HCC. Of the approximately 71 million individuals chronically infected …

SIRT1 in the development and treatment of hepatocellular carcinoma

M Farcas, AA Gavrea, D Gulei, C Ionescu… - Frontiers in …, 2019 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death
worldwide. Current treatment options for inoperable HCCs have decreased therapeutic …

DNA hypermethylation contributes to colorectal cancer metastasis by regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter

K Shao, W Pu, J Zhang, S Guo, F Qian, I Glurich… - Clinical …, 2021 - Springer
Background Aberrant DNA methylation has been firmly established as a factor contributing
to the pathogenesis of colorectal cancer (CRC) via its capacity to silence tumour suppressor …

Targeting the “undruggable”: rNA-binding proteins in the spotlight in cancer therapy

C Mir, Y Garcia-Mayea, ME Lleonart - Seminars in Cancer Biology, 2022 - Elsevier
Tumors refractory to conventional therapy belong to specific subpopulations of cancer cells,
which have acquired a higher number of mutations/epigenetic changes than the majority of …