Advances in toxicology and medical treatment of chemical warfare nerve agents
M Moshiri, E Darchini-Maragheh… - DARU Journal of …, 2012 - Springer
Abstract Organophosphorous (OP) Nerve agents (NAs) are known as the deadliest chemical
warfare agents. They are divided into two classes of G and V agents. Most of them are liquid …
warfare agents. They are divided into two classes of G and V agents. Most of them are liquid …
Exposure to nerve agents: from status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy
M de Araujo Furtado, F Rossetti, S Chanda, D Yourick - Neurotoxicology, 2012 - Elsevier
Epilepsy is a common neurological disorder characterized by an initial injury due to stroke,
traumatic brain injury, brain infection, or febrile seizures causing status epilepticus (SE). This …
traumatic brain injury, brain infection, or febrile seizures causing status epilepticus (SE). This …
Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification
RK Sit, VV Fokin, G Amitai, KB Sharpless… - Journal of medicinal …, 2014 - ACS Publications
Intoxication by organophosphate (OP) nerve agents and pesticides should be addressed by
efficient, quickly deployable countermeasures such as antidotes reactivating …
efficient, quickly deployable countermeasures such as antidotes reactivating …
Recent developments on oximes to improve the blood brain barrier penetration for the treatment of organophosphorus poisoning: a review
MNF Norrrahim, MAIA Razak, NAA Shah, H Kasim… - RSC …, 2020 - pubs.rsc.org
Organophosphorus (OP) compounds are highly toxic synthetic compounds which have been
used as pesticides and developed as warfare nerve agents. They represent a threat to both …
used as pesticides and developed as warfare nerve agents. They represent a threat to both …
Structure-activity relationship and efficacy of pyridinium oximes in the treatment of poisoning with organophosphorus compounds: a review of recent data
M Jokanovic - Current Topics in Medicinal Chemistry, 2012 - ingentaconnect.com
During more than five decades, pyridinium oximes have been developed as therapeutic
agents used in the medical treatment of poisoning with organophosphorus compounds …
agents used in the medical treatment of poisoning with organophosphorus compounds …
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro
F Worek, T Seeger, M Goldsmith, Y Ashani… - Archives of …, 2014 - Springer
The potent human toxicity of organophosphorus (OP) nerve agents calls for the development
of effective antidotes. Standard treatment for nerve agent poisoning with atropine and an …
of effective antidotes. Standard treatment for nerve agent poisoning with atropine and an …
Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study
F Worek, T Seeger, G Reiter, M Goldsmith, Y Ashani… - Toxicology Letters, 2014 - Elsevier
The highly toxic organophosphorus (OP) nerve agent VX is characterized by a remarkable
biological persistence which limits the effectiveness of standard treatment with atropine and …
biological persistence which limits the effectiveness of standard treatment with atropine and …
[图书][B] Retrometabolic drug design and targeting
N Bodor, P Buchwald - 2012 - books.google.com
Innovative approach to drug design that's more likely to result in an approvable drug product
Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft …
Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft …
Catalytic detoxification of organophosphorus nerve agents by butyrylcholinesterase-polymer-oxime bioscavengers
Organophosphorus nerve agents (OPNAs), used in chemical warfare, irreversibly inhibit
essential cholinesterases (ChEs) in the cholinergic neurotransmission system. Several …
essential cholinesterases (ChEs) in the cholinergic neurotransmission system. Several …
Tuning butyrylcholinesterase inactivation and reactivation by polymer‐based protein engineering
Organophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability
to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic …
to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic …