Abstract Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO,
plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …

The heme oxygenase (HO) system is essential for heme and iron homeostasis and
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …

SARS-CoV-2 is causing a pandemic resulting in high morbidity and mortality. COVID-19
patients suffering from acute respiratory distress syndrome (ARDS) are often critically ill and …

To better understand the tissue iron overload and anemia previously reported in a human
patient and mice that lack heme oxygenase-1 (HO-1), we studied iron distribution and …

Iron metabolism is vital for the survival of both humans and microorganisms. Heme
oxygenase-1 (HO-1) is an essential stress-response enzyme highly expressed in the lungs …

It is estimated that 10% of carbon throughout the cosmos is in the form of carbon monoxide
(CO). Earth's earliest prebiotic atmosphere included the trinity of gasotransmitters CO, nitric …

Heme oxygenase-1 (HO-1) is an enzyme that catalyzes the degradation of heme, releasing
equimolar amounts of carbon monoxide (CO), biliverdin (BV), and iron. The anti …

Coronaviruses are very large RNA viruses that originate in animal reservoirs and include
severe acute respiratory distress syndrome (SARS) and Middle East respiratory syndrome …

Upon injury, prolonged inflammation and oxidative stress may cause pathological wound
healing and fibrosis, leading to formation of excessive scar tissue. Fibrogenesis can occur in …

Diabetes mellitus is a clinically complex disease characterized by the dysfunctions of
pancreas. In this study, we investigated the therapeutic effects of ramulus mori …