Recent advances on quinazoline derivatives: A potential bioactive scaffold in medicinal chemistry
This paper intended to explore and discover recent therapeutic agents in the area of
medicinal chemistry for the treatment of various diseases. Heterocyclic compounds …
medicinal chemistry for the treatment of various diseases. Heterocyclic compounds …
In silico Methods for Design of Kinase Inhibitors as Anticancer Drugs
Rational drug design implies usage of molecular modeling techniques such as
pharmacophore modeling, molecular dynamics, virtual screening, and molecular docking to …
pharmacophore modeling, molecular dynamics, virtual screening, and molecular docking to …
Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: in vitro, in vivo, molecular docking, molecular dynamics, and …
Apparently, tubulin inhibitors binding to the colchicine-binding site (CBS) currently have
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
outstanding attention for cancer treatment. So, a series of benzo [b] azonin-2-one derivatives …
Synthesis of new substituted pyridine derivatives as potent anti-liver cancer agents through apoptosis induction: In vitro, in vivo, and in silico integrated approaches
ATA Boraei, EH Eltamany, IAI Ali, SM Gebriel… - Bioorganic …, 2021 - Elsevier
Liver cancer is the most common type of cancer in many countries. New studies and
statistics show rising liver cancer worldwide, so it is essential to seek new agents for this …
statistics show rising liver cancer worldwide, so it is essential to seek new agents for this …
Antiproliferative, antiangiogenic and apoptotic effect of new hybrids of quinazoline-4 (3H)-ones and sulfachloropyridazine
SS Zahran, FA Ragab, MG El-Gazzar… - European Journal of …, 2023 - Elsevier
Three new sets of quinazolinones bearing sulfachloropyridazine 4a-f, 6a-i and 8a-i were
designed and synthesized. All the synthesized compounds were screened for their in vitro …
designed and synthesized. All the synthesized compounds were screened for their in vitro …
Synthesis, characterization of some pyrazine derivatives as anti-cancer agents: In vitro and in Silico approaches
ES Tantawy, AM Amer, EK Mohamed… - Journal of Molecular …, 2020 - Elsevier
In continuation of our interest on the synthesis of fused quinoxalines and pyrazines
derivatives and due to the resultant pharmacological interest in compounds which belong to …
derivatives and due to the resultant pharmacological interest in compounds which belong to …
Design, synthesis and anticancer activity of novel 2-arylbenzimidazole/2-thiopyrimidines and 2-thioquinazolin-4 (3H)-ones conjugates as targeted RAF and VEGFR-2 …
IH Ali, HT Abdel-Mohsen, MM Mounier… - Bioorganic …, 2022 - Elsevier
In the current study, series of 2-arylbenzimidazole-thiopyrimidine and-thioquinazolin-4 (3H)-
ones conjugates 12a-d, 13a, b and 14a-l have been synthesized. All the synthesized …
ones conjugates 12a-d, 13a, b and 14a-l have been synthesized. All the synthesized …
Structure-based design, synthesis and antiproliferative action of new quinazoline-4-one/chalcone hybrids as EGFR inhibitors
A new series of quinazoline-4-one/chalcone hybrids, 7–26, was synthesized in this study as
EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in …
EGFR inhibitors with antiproliferative activity. Target compounds were synthesized and in …
Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)-s-triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling …
Here, we synthesized a newseries of mono-and bis (dimethylpyrazolyl)-s-triazine
derivatives. The synthetic methodology involved the reaction of different mono-and …
derivatives. The synthetic methodology involved the reaction of different mono-and …
Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids
The major enzyme responsible for the hydrolytic breakdown of the neurotransmitter
acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors …
acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors …