Directional cell migration is required for proper embryogenesis, immunity, and healing, and
its underpinning regulatory mechanisms are often hijacked during diseases such as chronic …

Abstract β-catenin is widely regarded as the primary transducer of canonical WNT signals to
the nucleus. In most vertebrates, there are eight additional catenins that are structurally …

Molecular analysis of the cadherin-catenin complex elucidated the central role of β-catenin
in this adhesion complex, as it binds to the cytoplasmic domain of E-cadherin and to α …

The cadherin-catenin complex has an important role in cell-cell adhesion and may also
function in signaling pathways. We report that overexpression of three cadherin types in …

The question of how dorsal-ventral polarity is established in vertebrates is central to our
understanding of their early development. Several lines of evidence suggest that wnt …

We identified two cadherins, c-cad6B and c-cad7, expressed by neural crest cells at their
premigratory and migratory stages, respectively, in chicken embryos. cDNA transfection …

The carboxyl terminus-truncated cadherin (nonfunctional cadherin) has no cell adhesion
activity probably because of its failure to associate with cytoplasmic proteins called alpha …

Background: During cytokinesis in animal cells, an equatorial actomyosin-based contractile
ring divides the cell into two daughter cells. The position of the contractile ring is specified by …

Axin was originally identified from the characterization of the Fused locus, the disruption of
which leads to duplication of axis and embryonic lethality. It is a multidomain protein that …

Somite formation in the mouse embryo begins with the recruitment of mesenchymal cells
into the paraxial mesoderm. Cells destined for the paraxial mesoderm are recruited from a …