The role of phosphatidylserine recognition receptors in multiple biological functions

MB Naeini, V Bianconi, M Pirro, A Sahebkar - Cellular & molecular biology …, 2020 - Springer
Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis.
Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase …

Efferocytosis in the tumor microenvironment

TA Werfel, RS Cook - Seminars in immunopathology, 2018 - Springer
Within the course of a single minute, millions of cells in the human body will undergo
programmed cell death in response to physiological or pathological cues. The diminished …

Don't eat me/eat me signals as a novel strategy in cancer immunotherapy

A Khalaji, FB Yancheshmeh, F Farham, A Khorram… - Heliyon, 2023 - cell.com
Cancer stands as one of the prominent global causes of death, with its incidence burden
continuously increasing, leading to a substantial rise in mortality rates. Cancer treatment has …

Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling

HJ Kim, K Yang, K Kim, YJ Lee, S Lee… - Cellular & molecular …, 2022 - nature.com
The interplay between apoptotic cancer cells and the tumor microenvironment modulates
cancer progression and metastasis. Cancer-associated fibroblasts (CAFs) play a crucial role …

Determining the effector response to cell death

CV Rothlin, TD Hille, S Ghosh - Nature Reviews Immunology, 2021 - nature.com
Cell death occurs when a pathogen invades a host organism or the organism is subjected to
sterile injury. Thus, cell death is often closely associated with the induction of an immune …

Regulation of efferocytosis as a novel cancer therapy

Y Zhou, Y Yao, Y Deng, A Shao - Cell Communication and Signaling, 2020 - Springer
Efferocytosis is a physiologic phagocytic clearance of apoptotic cells, which modulates
inflammatory responses and the immune environment and subsequently facilitates immune …

HPV DNA associates with breast cancer malignancy and it is transferred to breast cancer stromal cells by extracellular vesicles

S De Carolis, G Storci, C Ceccarelli, C Savini… - Frontiers in …, 2019 - frontiersin.org
A causal link between Human Papillomavirus (HPV) and breast cancer (BC) remains
controversial. In spite of this, the observation that HPV DNA is over-represented in the Triple …

Immunomodulation of wound healing leading to efferocytosis

Y Zhao, M Li, J Mao, Y Su, X Huang, W Xia… - Smart …, 2024 - Wiley Online Library
Effectively eliminating apoptotic cells is precisely controlled by a variety of signaling
molecules and a phagocytic effect known as efferocytosis. Abnormalities in efferocytosis …

Exosomes and other extracellular vesicles in HPV transmission and carcinogenesis

D Guenat, F Hermetet, JL Prétet, C Mougin - Viruses, 2017 - mdpi.com
Extracellular vesicles (EVs), including exosomes (Exos), microvesicles (MVs) and apoptotic
bodies (ABs) are released in biofluids by virtually all living cells. Tumor-derived Exos and …

Efferocytosis of pathogen-infected cells

N Karaji, QJ Sattentau - Frontiers in immunology, 2017 - frontiersin.org
The prompt and efficient clearance of unwanted and abnormal cells by phagocytes is termed
efferocytosis and is crucial for organism development, maintenance of tissue homeostasis …