Simple Summary The canonical WNT/β-catenin pathway is upregulated in cancers and
plays a major role in proliferation, invasion, apoptosis and angiogenesis. Recent studies …

Highlights•Hepatic stellate cell activation/myofibroblast transition is the main driver of liver
fibrosis.•Paracrine signals from adjacent cells induce stellate cell activation.•Alteration in …

Osteosarcoma (OS) therapy faces many challenges, especially the poor survival rate once
metastasis occurs. Therefore, it is crucial to explore new OS treatment strategies that can …

Simple Summary Wnt has diverse regulatory roles at multiple cellular levels and numerous
targeting points, and aberrant Wnt signaling has crucial roles in carcinogenesis, metastasis …

Glioblastoma multiforme is one of the calamitous primary glial brain tumors with extensive
heterogeneity at cellular and molecular levels. While maximal surgical resection trailed by …

Autophagy is a conserved cellular process required to maintain homeostasis. The hallmark
of autophagy is the formation of a phagophore that engulfs cytosolic materials for …

Colorectal cancer (CRC) pathogenesis is mainly driven by alterations in WNT signaling,
which results in altered transcriptional activity of β-Catenin. Mutations in APC (Adenomatous …

Renal cell carcinoma (RCC), also called kidney cancer, is one of the most common
malignancies worldwide, including the United States and China. Because of the …

Colorectal cancer (CRC) continues to be one of the main causes of death from cancer
because patients progress unfavorably due to resistance to current therapies. Dysregulation …

Targeting specific molecular drivers of tumor growth is a key approach in cancer therapy.
Among these targets, the low-density lipoprotein receptor-related protein 6 (LRP6), a vital …