Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

Congenital lung malformations

F Pederiva, SS Rothenberg, N Hall… - Nature Reviews …, 2023 - nature.com
Congenital lung malformations (CLMs) are rare developmental anomalies of the lung,
including congenital pulmonary airway malformations (CPAM), bronchopulmonary …

MicroRNAs: from mechanism to organism

PJ Dexheimer, L Cochella - Frontiers in cell and developmental …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …

Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

The non-canonical aspects of microRNAs: many roads to gene regulation

CJ Stavast, SJ Erkeland - Cells, 2019 - mdpi.com
MicroRNAs (miRNAs) are critical regulators of gene expression. As miRNAs are frequently
deregulated in many human diseases, including cancer and immunological disorders, it is …

Role of miRNA-regulated cancer stem cells in the pathogenesis of human malignancies

AQ Khan, EI Ahmed, NR Elareer, K Junejo, M Steinhoff… - Cells, 2019 - mdpi.com
Recent biomedical discoveries have revolutionized the concept and understanding of
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic …

An overview of microRNAs

SM Hammond - Advanced drug delivery reviews, 2015 - Elsevier
The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …

Regulation of microRNA biogenesis

M Ha, VN Kim - Nature reviews Molecular cell biology, 2014 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

Adult stem cells at work: regenerating skeletal muscle

M Schmidt, SC Schüler, SS Hüttner, B von Eyss… - Cellular and Molecular …, 2019 - Springer
Skeletal muscle regeneration is a finely tuned process involving the activation of various
cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are …

miRNA dosage control in development and human disease

Y Cui, Y Qi, L Ding, S Ding, Z Han, Y Wang, P Du - Trends in Cell Biology, 2024 - cell.com
In mammals, miRNAs recognize target mRNAs via base pairing, which leads to a complex
'multiple-to-multiple'regulatory network. Previous studies have focused on the regulatory …