Alignment-free sequence analyses have been applied to problems ranging from whole-
genome phylogeny to the classification of protein families, identification of horizontally …

The compilation of multiple metazoan genome sequences and the deluge of large-scale
expression data have combined to motivate the maturation of bioinformatics methods for the …

The evolution of land flora transformed the terrestrial environment. Land plants evolved from
an ancestral charophycean alga from which they inherited developmental, biochemical, and …

New genome assemblies have been arriving at a rapidly increasing pace, thanks to
decreases in sequencing costs and improvements in third-generation sequencing …

The Ensembl gene annotation system has been used to annotate over 70 different
vertebrate species across a wide range of genome projects. Furthermore, it generates the …

Abstract NONCODE (http://www. bioinfo. org/noncode/) is an interactive database that aims
to present the most complete collection and annotation of non-coding RNAs, especially long …

Genome sequence analysis has enabled significant advancements in medical and scientific
areas such as personalized medicine, outbreak tracing, and the understanding of evolution …

Background For the last 25 years species delimitation in prokaryotes (Archaea and Bacteria)
was to a large extent based on DNA-DNA hybridization (DDH), a tedious lab procedure …

Evolution provides the unifying framework with which to understand biology. The coherent
investigation of genic and genomic data often requires comparative genomics analyses …

Rosaceae is the most important fruit-producing clade, and its key commercially relevant
genera (Fragaria, Rosa, Rubus and Prunus) show broadly diverse growth habits, fruit types …