Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology
Cancer nanotherapeutics are progressing at a steady rate; research and development in the
field has experienced an exponential growth since early 2000's. The path to the …
field has experienced an exponential growth since early 2000's. The path to the …
[HTML][HTML] Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent advances in cancer treatment
P Graván, A Aguilera-Garrido, JA Marchal… - Advances in Colloid and …, 2023 - Elsevier
Nanotechnological drug delivery platforms represent a new paradigm for cancer
therapeutics as they improve the pharmacokinetic profile and distribution of …
therapeutics as they improve the pharmacokinetic profile and distribution of …
Ligand density on nanoparticles: A parameter with critical impact on nanomedicine
Nanoparticles modified with ligands for specific targeting towards receptors expressed on
the surface of target cells are discussed in literature towards improved delivery strategies. In …
the surface of target cells are discussed in literature towards improved delivery strategies. In …
Small molecules as cancer targeting ligands: Shifting the paradigm
Conventional chemotherapeutics exploration is hampered due to their nonspecific
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
distribution leading to unintended serious toxicity. Toxicity is so severe that deciding to go for …
Advances in receptor‐mediated, tumor‐targeted drug delivery
Receptor‐mediated drug delivery presents an opportunity to enhance therapeutic efficiency
by accumulating drug within the tissue of interest and reducing undesired, off‐target effects …
by accumulating drug within the tissue of interest and reducing undesired, off‐target effects …
Nanoparticle heterogeneity: an emerging structural parameter influencing particle fate in biological media?
JM Rabanel, V Adibnia, SF Tehrani, S Sanche… - Nanoscale, 2019 - pubs.rsc.org
Drug nanocarriers' surface chemistry is often presumed to be uniform. For instance, the
polymer surface coverage and distribution of ligands on nanoparticles are described with …
polymer surface coverage and distribution of ligands on nanoparticles are described with …
Biomedical nanoparticle design: What we can learn from viruses
SM Figueroa, D Fleischmann, A Goepferich - Journal of Controlled Release, 2021 - Elsevier
Viruses are nanomaterials with a number of properties that surpass those of many synthetic
nanoparticles (NPs) for biomedical applications. They possess a rigorously ordered …
nanoparticles (NPs) for biomedical applications. They possess a rigorously ordered …
Enhanced human epidermal growth factor receptor 2 degradation in breast cancer cells by lysosome-targeting gold nanoconstructs
This paper describes how gold nanoparticle nanoconstructs can enhance anticancer effects
of lysosomal targeting aptamers in breast cancer cells. Nanoconstructs consisting of anti …
of lysosomal targeting aptamers in breast cancer cells. Nanoconstructs consisting of anti …
Nanoparticle multivalency directed shifting of cellular uptake mechanism
Although nanoparticle multivalency is known to influence their biological labeling
performance, the functional role of multivalency is largely unexplored. Here we show that the …
performance, the functional role of multivalency is largely unexplored. Here we show that the …
Multivalency in drug delivery–when is it too much of a good thing?
KC Tjandra, P Thordarson - Bioconjugate chemistry, 2019 - ACS Publications
Multivalency plays a large role in many biological and synthetic systems. The past 20 years
of research have seen an explosion in the study of multivalent drug delivery systems based …
of research have seen an explosion in the study of multivalent drug delivery systems based …