Next-generation materials for RNA–lipid nanoparticles: lyophilization and targeted transfection
T Wang, TC Sung, T Yu, HY Lin, YH Chen… - Journal of Materials …, 2023 - pubs.rsc.org
RNA, including mRNA, siRNA and miRNA, is part of a new class of patient treatments that
prevent and treat several diseases. As an alternative to DNA therapy using plasmid DNA …
prevent and treat several diseases. As an alternative to DNA therapy using plasmid DNA …
Respiratory viruses and virus-like particle vaccine development: how far have we advanced?
KB Chu, FS Quan - Viruses, 2023 - mdpi.com
With technological advancements enabling globalization, the intercontinental transmission
of pathogens has become much easier. Respiratory viruses are one such group of …
of pathogens has become much easier. Respiratory viruses are one such group of …
Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine
M Li, L Jia, Y Xie, W Ma, Z Yan, F Liu, J Deng, A Zhu… - npj Vaccines, 2023 - nature.com
Some studies have shown that lyophilization significantly improves the stability of mRNA-
LNPs and enables long-term storage at 2–8° C. However, there is little research on the …
LNPs and enables long-term storage at 2–8° C. However, there is little research on the …
Design and lyophilization of mRNA-encapsulating lipid nanoparticles
T Wang, T Yu, W Li, Q Liu, TC Sung… - International Journal of …, 2024 - Elsevier
The remarkable success of two FDA-approved mRNA-encapsulating vaccines (Comirnaty®
and Spikevax®) indicated the importance of lipid nanoparticles (LNPs) delivery systems in …
and Spikevax®) indicated the importance of lipid nanoparticles (LNPs) delivery systems in …
[HTML][HTML] Protection of K18-hACE2 Mice against SARS-CoV-2 Challenge by a Capsid Virus-like Particle-Based Vaccine
SK Myeni, AA Leijs, PJ Bredenbeek, ST Morales… - Vaccines, 2024 - ncbi.nlm.nih.gov
The SARS-CoV-2 pandemic and the emergence of novel virus variants have had a dramatic
impact on public health and the world economy, underscoring the need for detailed studies …
impact on public health and the world economy, underscoring the need for detailed studies …
[HTML][HTML] Leveraging Immunofocusing and Virus-like Particle Display to Enhance Antibody Responses to the Malaria Blood-Stage Invasion Complex Antigen PfCyRPA
KH Björnsson, MR Bassi, AS Knudsen, KL Aves… - Vaccines, 2024 - mdpi.com
A vaccine protecting against malaria caused by Plasmodium falciparum is urgently needed.
The blood-stage invasion complex PCRCR consists of the five malarial proteins PfPTRAMP …
The blood-stage invasion complex PCRCR consists of the five malarial proteins PfPTRAMP …