Ischemic heart disease (IHD) remains the leading cause of death and disability worldwide.
For patients presenting with an acute myocardial infarction, the most effective treatment for …

The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein
kinase that senses multiple upstream stimuli to control cell growth, metabolism, and …

Ischaemic heart disease (IHD) remains a major cause of morbidity/mortality globally, firmly
established in W esternized or 'developed'countries and rising in prevalence in developing …

Aging impairs the mitochondrial electron transport chain (ETC), especially in interfibrillar
mitochondria (IFM). Mitochondria are in close contact with the endoplasmic reticulum (ER) …

Hypoxia, a hallmark characteristic of glioblastoma (GBM) induces changes in the
transcriptome and the proteome of tumor cells. We discovered that hypoxic stress produces …

Background: Senescent cardiomyocytes exhibit a mismatch between energy demand and
supply that facilitates their transition toward failing cells. Altered calcium transfer from …

This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …

Translation of cardioprotective interventions aimed at reducing myocardial injury during
ischaemia–reperfusion from experimental studies to clinical practice is an important yet …

Advanced age is a major predisposing risk factor for the incidence of coronary syndromes
and comorbid conditions which impact the heart response to cardioprotective interventions …

Mitochondria have long been known to be the gatekeepers of cell fate. This is particularly so
in the response to acute ischaemia‐reperfusion injury (IRI). Following an acute episode of …