Role of ex vivo Expanded Mesenchymal Stromal Cells in Determining Hematopoietic Stem Cell Transplantation Outcome
S Crippa, L Santi, M Berti, G De Ponti… - Frontiers in Cell and …, 2021 - frontiersin.org
Overall, the human organism requires the production of∼ 1 trillion new blood cells per day.
Such goal is achieved via hematopoiesis occurring within the bone marrow (BM) under the …
Such goal is achieved via hematopoiesis occurring within the bone marrow (BM) under the …
Mesenchymal COX 2‐PG secretome engages NR 4A‐WNT signalling axis in haematopoietic progenitors to suppress anti‐leukaemia immunity
The bone marrow (BM) microenvironment (niche) plays important roles in supporting
normal/abnormal haematopoiesis. We investigated the interaction between leukaemic …
normal/abnormal haematopoiesis. We investigated the interaction between leukaemic …
ASCs Activate cGAS-Type I IFNs-IL-7 Axis Via Pseudomonas aeruginosa-Derived Outer Membrane Vesicles to Resolve Pneumonia
C Di, Y Jiang, L Li, M Shi, Y Zhu, J Zhang, Y Song… - Stem Cells, 2023 - academic.oup.com
Mesenchymal stem cells (MSCs) therapy could efficiently attenuate LPS-induced acute lung
injury and Pseudomonas aeruginosa (PA)-induced acute pneumonia. However, the …
injury and Pseudomonas aeruginosa (PA)-induced acute pneumonia. However, the …
Lipidomic profiling links the Fanconi anemia pathway to glycosphingolipid metabolism in head and neck cancer cells
X Zhao, MG Brusadelli, S Sauter, M Butsch Kovacic… - Clinical Cancer …, 2018 - AACR
Abstract Purpose: Mutations in Fanconi anemia (FA) genes are common in sporadic
squamous cell carcinoma of the head and neck (HNSCC), and we have previously …
squamous cell carcinoma of the head and neck (HNSCC), and we have previously …
Multiparametric analysis of etoposide exposed mesenchymal stem cells and Fanconi anemia cells: implications in development of secondary myeloid malignancy
C Özdemir, B Muratoğlu, BN Özel… - Clinical and …, 2023 - Springer
Secondary acute myeloid leukemia (sAML) may develop following a prior therapy or may
evolve from an antecedent hematological disorder such as Fanconi Anemia (FA) …
evolve from an antecedent hematological disorder such as Fanconi Anemia (FA) …
[HTML][HTML] An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in Fanconi anemia
Y Zhou, Y He, W Xing, P Zhang, H Shi, S Chen… - …, 2017 - ncbi.nlm.nih.gov
Fanconi anemia is a complex heterogeneous genetic disorder with a high incidence of bone
marrow failure, clonal evolution to acute myeloid leukemia and mesenchymal-derived …
marrow failure, clonal evolution to acute myeloid leukemia and mesenchymal-derived …
Importance of finding the bona fide target of the Fanconi anemia pathway
W Sakai, K Sugasawa - Genes and Environment, 2019 - Springer
Fanconi anemia (FA) is a rare genetic disease characterized by the deficiency of the cellular
response and repair pathway for DNA interstrand crosslink (ICL) damage. Although recent …
response and repair pathway for DNA interstrand crosslink (ICL) damage. Although recent …
In vivo RNAi screen unveils PPARγ as a regulator of hematopoietic stem cell homeostasis
Hematopoietic stem cell (HSC) defects can cause repopulating impairment leading to
hematologic diseases. To target HSC deficiency in a disease setting, we exploited the …
hematologic diseases. To target HSC deficiency in a disease setting, we exploited the …
Fanca deficiency is associated with alterations in osteoclastogenesis that are rescued by TNFα
A Oppezzo, L Monney, H Kilian, L Slimani… - Cell & Bioscience, 2023 - Springer
Abstract Background Hematopoietic stem cells (HSCs) reside in the bone marrow (BM)
niche, which includes bone-forming and bone-resorbing cells, ie, osteoblasts (OBs) and …
niche, which includes bone-forming and bone-resorbing cells, ie, osteoblasts (OBs) and …
Reduced cell division control protein 42 activity compromises hematopoiesis-supportive function of Fanconi anemia mesenchymal stromal cells
Hematopoietic stem cells preserve their ability to self-renew and differentiate to different
lineages in the bone marrow (BM) niche, which is composed in large part by BM stromal …
lineages in the bone marrow (BM) niche, which is composed in large part by BM stromal …