Overall, the human organism requires the production of∼ 1 trillion new blood cells per day.
Such goal is achieved via hematopoiesis occurring within the bone marrow (BM) under the …

The bone marrow (BM) microenvironment (niche) plays important roles in supporting
normal/abnormal haematopoiesis. We investigated the interaction between leukaemic …

Mesenchymal stem cells (MSCs) therapy could efficiently attenuate LPS-induced acute lung
injury and Pseudomonas aeruginosa (PA)-induced acute pneumonia. However, the …

Abstract Purpose: Mutations in Fanconi anemia (FA) genes are common in sporadic
squamous cell carcinoma of the head and neck (HNSCC), and we have previously …

Secondary acute myeloid leukemia (sAML) may develop following a prior therapy or may
evolve from an antecedent hematological disorder such as Fanconi Anemia (FA) …

Fanconi anemia is a complex heterogeneous genetic disorder with a high incidence of bone
marrow failure, clonal evolution to acute myeloid leukemia and mesenchymal-derived …

Fanconi anemia (FA) is a rare genetic disease characterized by the deficiency of the cellular
response and repair pathway for DNA interstrand crosslink (ICL) damage. Although recent …

Hematopoietic stem cell (HSC) defects can cause repopulating impairment leading to
hematologic diseases. To target HSC deficiency in a disease setting, we exploited the …

Abstract Background Hematopoietic stem cells (HSCs) reside in the bone marrow (BM)
niche, which includes bone-forming and bone-resorbing cells, ie, osteoblasts (OBs) and …

Hematopoietic stem cells preserve their ability to self-renew and differentiate to different
lineages in the bone marrow (BM) niche, which is composed in large part by BM stromal …