The recognition and management of life-threatening hemorrhage in the polytrauma patient
poses several challenges to prehospital rescue personnel and hospital providers. First …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Fibrinogen is crucial for the formation of blood clot and clinical outcomes in major bleeding.
Both Thromboelastography (TEG) and Rotational Thromboelastometry (ROTEM) have been …

Background Fibrinogen is the first coagulation protein to reach critical levels during
traumatic haemorrhage. This laboratory study compares paired plasma samples pre-and …

Introduction Fibrinogen plays a key role in hemostasis and is the first coagulation factor to
reach critical levels in massively bleeding trauma patients. Consequently, rapid estimation of …

Fibrinogen plays an essential role in clot formation and stability. Importantly it seems to be
the most vulnerable coagulation factor, reaching critical levels earlier than the others during …

The dose-dependent risk of dilutional coagulopathy differs between colloids (dextran>
hetastarch> pentastarch> tetrastarch, gelatins> albumin). Risk awareness includes …

This is a narrative review of the published evidence for bleeding management in critically ill
patients in different clinical settings in the intensive care unit (ICU). We aimed to describe …

Purpose Uncontrolled bleeding is the main preventable cause of death in severe trauma
patients. Fibrinogen is the first coagulation factor to decrease during trauma-induced …