The allene functionality has participated in one of the most exciting voyages in organic
chemistry, from chemical curiosities to a recurring building block in modern organic …

Conspectus So far, over 150 natural products and pharmaceuticals containing an allene
moiety have been identified. During the last two decades, allenes have also been …

Capitalizing a synergy between late-stage C (sp3)–H alkynylation and a series of transition
metal-catalyzed alkyne functionalization reactions, we reported herein enantioselective …

Tetrasubstituted propargylamines comprise a unique class of highly useful compounds,
which can be accessed through the multicomponent coupling between ketones, amines …

Herein, we report a general and practical nickel-catalyzed deaminative allenylation of amino
acid derivatives with terminal alkynes. The well-designed, electron deficient, and sterically …

A novel visible-light-induced 1, 4-hydroxysulfonylation of vinyl enynes with sulfonyl chlorides
has been established, providing a highly efficient protocol to access multisubstituted sulfonyl …

Transition-metal-catalyzed direct Csingle bondH functionalization utilizing unsaturated
hydrocarbons have been established as a robust strategy to increase molecular complexity …

A rhodium-catalyzed C–H functionalization-based intermolecular allylation of indoles with
trisubstituted allenes has been developed. This synthetic process proceeds with an …

Development of the self-assembled monolayer/MALDI mass spectrometry (SAMDI) platform
to enable a high-throughput optimization of a traceless Petasis reaction is described. More …

A straightforward, user-friendly, efficient protocol for the one pot, ZnI2-catalyzed allenylation
of terminal alkynes with pyrrolidine and ketones, toward trisubstituted allenes, is described …