Inflammasome components as new therapeutic targets in inflammatory disease
RC Coll, K Schroder - Nature Reviews Immunology, 2024 - nature.com
Inflammation drives pathology in many human diseases for which there are no disease-
modifying drugs. Inflammasomes are signalling platforms that can induce pathological …
modifying drugs. Inflammasomes are signalling platforms that can induce pathological …
Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models
HY Zheng, TZ Song, YT Zheng - Zoological Research, 2024 - pmc.ncbi.nlm.nih.gov
The distribution of the immune system throughout the body complicates in vitro assessments
of coronavirus disease 2019 (COVID-19) immunobiology, often resulting in a lack of …
of coronavirus disease 2019 (COVID-19) immunobiology, often resulting in a lack of …
Lessons Learned From Clinical Trials of Immunotherapeutics for COVID‐19
I Lee, CR Lupfer - Immunological Reviews, 2024 - Wiley Online Library
The COVID‐19 pandemic caused by the SARS‐CoV‐2 virus was arguably one of the worst
public health disasters of the last 100 years. As many infectious disease experts were …
public health disasters of the last 100 years. As many infectious disease experts were …
Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants
H Maaß, M Ynga-Durand, M Milošević, F Krstanović… - Scientific Reports, 2024 - nature.com
The aim of this study was to characterize the systemic cytokine signature of critically ill
COVID-19 patients in a high mortality setting aiming to identify biomarkers of severity, and to …
COVID-19 patients in a high mortality setting aiming to identify biomarkers of severity, and to …
Adult-Onset Still's Disease (AOSD): Advances in Understanding Pathophysiology, Genetics and Emerging Treatment Options
Adult-onset Still's disease (AOSD) is a multisystemic complex disorder clinically
characterised by episodes of spiking fever, evanescent rash, polyarthritis or diffuse …
characterised by episodes of spiking fever, evanescent rash, polyarthritis or diffuse …
Long-term efficacy of MAS825, a bispecific anti-IL1β and IL-18 monoclonal antibody, in two patients with systemic JIA and recurrent episodes of macrophage …
R Caorsi, A Bertoni, C Matucci-Cerinic, V Natoli… - …, 2024 - academic.oup.com
Abstract Introduction Systemic JIA (sJIA), a multifaceted autoinflammatory disorder, can be
complicated by life-threatening conditions such as macrophage activation syndrome (MAS) …
complicated by life-threatening conditions such as macrophage activation syndrome (MAS) …
[HTML][HTML] IL-18 and IL-18BP: A Unique Dyad in Health and Disease
D Novick - International Journal of Molecular Sciences, 2024 - mdpi.com
Interleukin-18 (IL-18) serves a dual function in the immune system, acting as a “double-
edged sword” cytokine. Depending on the microenvironment and timing, IL-18 can either …
edged sword” cytokine. Depending on the microenvironment and timing, IL-18 can either …
[PDF][PDF] Marina Pribanić Matešić 4, Iva Žuža 5, Stipan Jonjić 4, Ilija Brizić 4, Alan Šustić 3, 6, Frank Bloos 7, SepNet Critical Care Trials Group, Alen Protić 3 & Luka Čičin …
H Maaß, M Ynga‑Durand, M Milošević… - Scientific …, 2024 - scienceopen.com
The aim of this study was to characterize the systemic cytokine signature of critically ill
COVID‑19 patients in a high mortality setting aiming to identify biomarkers of severity, and to …
COVID‑19 patients in a high mortality setting aiming to identify biomarkers of severity, and to …
Mechanismy dysregulace imunitního systému u vrozených poruch imunity
J Smetanová - 2024 - dspace.cuni.cz
Primární imunodeficience (PID) jsou vzácně se vyskytující skupinou vrozených poruch
imunity zahrnující více než 485 onemocnění, která se klasifikují do deseti skupin na základě …
imunity zahrnující více než 485 onemocnění, která se klasifikují do deseti skupin na základě …