The widespread applications of benzophenone (BP) photochemistry in biological chemistry,
bioorganic chemistry, and material science have been prominent in both academic and …

Nearly all FDA approved drugs and bioactive small molecules exert their effects by binding
to and modulating proteins. Consequently, understanding how small molecules interact with …

Activity-based protein profiling (ABPP) has become an emerging chemical proteomic
approach to illustrate the interaction mechanisms between compounds and proteins. This …

Advances in genomic analyses enable the identification of new proteins that are associated
with disease. To validate these targets, tool molecules are required to demonstrate that a …

This review discusses the advances in metabolic oligosaccharide engineering (MOE) from
2010 to 2016 with a focus on the structure, preparation, and reactivity of its chemical probes …

The CDK family plays a crucial role in the control of the cell cycle. Dysregulation and
mutation of the CDKs has been implicated in cancer and the CDKs have been investigated …

Photoaffinity labeling is a well-known biochemical technique that has grown significantly
since the turn of the century, principally due to its combination with bioorthogonal/click …

A concise and enantioselective total synthesis of the potent PI3K inhibitor (+)-wortmannin is
described. A Pd-catalyzed cascade reaction was first developed to connect a synthon …

In the past decade, there has been increasing interest in use of small molecules for
immunomodulation. The affinity-based pull-down purification is an essential tool for target …

The dynamic proteome plays numerous roles in the interactions of microbes—whether they
are invading pathogens or symbiotic organisms—and their hosts. Host and microbe sense …