Emergent simplicities in the living histories of individual cells

CS Wright, K Joshi, RR Biswas… - Annual Review of …, 2024 - annualreviews.org
Organisms maintain the status quo, holding key physiological variables constant to within an
acceptable tolerance, and yet adapt with precision and plasticity to dynamic changes in …

Optimal harvesting policy for biological resources with uncertain heterogeneity for application in fisheries management

H Yoshioka - Natural Resource Modeling, 2024 - Wiley Online Library
Conventional harvesting problems for natural resources often assume physiological
homogeneity of the body length/weight among individuals. However, such assumptions …

Optimal control of ribosome population for gene expression under periodic nutrient intake

C Soubrier, E Foxall, L Ciandrini… - Journal of the Royal …, 2024 - royalsocietypublishing.org
Translation of proteins is a fundamental part of gene expression that is mediated by
ribosomes. As ribosomes significantly contribute to both cellular mass and energy …

Optimisation of gene expression noise for cellular persistence against lethal events

P Bokes, A Singh - Journal of Theoretical Biology, 2025 - Elsevier
Bacterial cell persistence, crucial for survival under adverse conditions like antibiotic
exposure, is intrinsically linked to stochastic fluctuations in gene expression. Certain genes …

Revisiting moment-closure methods with heterogeneous multiscale population models

D Lunz, JF Bonnans, J Ruess - Mathematical Biosciences, 2022 - Elsevier
Stochastic chemical kinetics at the single-cell level give rise to heterogeneous populations
of cells even when all individuals are genetically identical. This heterogeneity can lead to …

The Meaning and Accuracy of the Improving Functions in the Solution of the CBQR by Krotov's Method

I Halperin - Mathematics, 2024 - mdpi.com
A new solution to the continuous-time bilinear quadratic regulator optimal control problem
(CBQR) was recently developed using Krotov's Method. This paper provides two theoretical …

Modeling and Optimal Control of a Two-Species Bioproducing Microbial Consortium

D Lunz, J Frédéric Bonnans - SIAM Journal on Applied Mathematics, 2023 - SIAM
Motivated by recent laboratory experiments, we study microbial populations with light-
inducible genetic differentiation that generates a two-species microbial consortium relevant …

Hysteresis and noise floor in gene expression optimised for persistence against lethal events

P Bokes, A Singh - bioRxiv, 2024 - biorxiv.org
Bacterial cell persistence, crucial for survival under adverse conditions like antibiotic
exposure, is intrinsically linked to stochastic fluctuations in gene expression. Certain genes …

[PDF][PDF] Revisiting moment closure methods with population models

D Lunz, JF Bonnans, J Ruess - 2021 - researchgate.net
Stochastic chemical kinetics at the single-cell level give rise to heterogeneous populations
of cells even when all individuals are genetically identical. This heterogeneity can lead to …