Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Anatomic pathology studies performed over 150 years ago revealed that excessive
activation of coagulation occurs in the setting of inflammation. However, it has taken over a …

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is
activated and complement is regulated, wrote,“In the study of biological processes, the …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has been led to a pandemic emergency. So far …

Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication in patients
with hematologic malignancies or systemic autoimmune disorders. Pathologic findings show …

COVID-19 progression often involves severe lung injury, inflammation, coagulopathy, and
leukocyte infiltration into pulmonary tissues. The pathogenesis of these complications is …

In SARS-CoV-2-infected humans, disease progression is often associated with acute
respiratory distress syndrome involving severe lung injury, coagulopathy, and thrombosis of …

Anabolic androgenic steroid (AAS) abuse surged during the 1980s and is seen in
approximately 1 in 20 of all males today. A wide spectrum of AAS compounds and abuse …

Patients with severe hemophilia A (HA) have an increased risk of spontaneous and trauma‐
related bleeding because of a congenital absence of factor VIII (FVIII). Most severe HA …