Abstract Epithelial-mesenchymal transitions (EMTs), the acquisition of mesenchymal
features from epithelial cells, occur during some biological processes and are classified into …

Immunotherapy holds great promise for the treatment of pediatric cancers. In neuroblastoma,
the recent implementation of anti-GD2 antibody Dinutuximab into the standard of care has …

N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be
installed by the methyltransferase complex and removed by demethylases, which are …

Neuroblastoma (NB) is a malignant embryonal tumor of the sympathetic nervous system that
is most commonly diagnosed in the abdomen, often presenting with signs and symptoms of …

The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of
immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti …

Peripheral neuroblastic tumors (PNTs) represent a spectrum of neural-crest-derived tumors,
including neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Malignant cells in …

Neuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the
neural crest and accounts for more than 15% of all the childhood deaths from cancer. The …

Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their
regenerative and immunomodulatory properties. They are capable of modulating …

The presence of functionally efficient cytotoxic T lymphocytes (CTL) in the Tumour nest is
crucial in mediating a successful immune response to cancer. The detection and elimination …

Neuroblastoma is the most common extracranial pediatric tumor and often presents with
metastatic disease, and patients with high-risk neuroblastoma have survival rates of~ 50 …