From target discovery to clinical drug development with human genetics
The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …
decades were anticipated to result in many innovative therapies. Here we investigate the …
Genetics of chronic respiratory disease
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease
Background Mitochondrial dysfunction has been linked to the development of inflammatory
bowel disease (IBD), but the genetic pathophysiology was not fully elucidated. We employed …
bowel disease (IBD), but the genetic pathophysiology was not fully elucidated. We employed …
Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
Background We aimed to investigate the protein pathways linking obesity and lifestyle
factors to coronary artery disease (CAD). Methods Summary-level genome-wide association …
factors to coronary artery disease (CAD). Methods Summary-level genome-wide association …
Causal relationships between screen use, reading, and brain development in early adolescents
The rise of new media has greatly changed the lifestyles, leading to increased time on these
platforms and less time spent reading. This shift has particularly profound impacts on early …
platforms and less time spent reading. This shift has particularly profound impacts on early …
Alternative splicing in lung influences COVID-19 severity and respiratory diseases
Alternative splicing generates functional diversity in isoforms, impacting immune response to
infection. Here, we evaluate the causal role of alternative splicing in COVID-19 severity and …
infection. Here, we evaluate the causal role of alternative splicing in COVID-19 severity and …
Gut microbiota and cognitive performance: A bidirectional two-sample Mendelian randomization
Q Wang, Y Song, X Wu, Y Luo, R Miao, X Yu… - Journal of Affective …, 2024 - Elsevier
Purpose Previous studies have suggested a potential association between gut microbiota
and neurological and psychiatric disorders. However, the causal relationship between gut …
and neurological and psychiatric disorders. However, the causal relationship between gut …
Circulating proteins to predict COVID-19 severity
Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully
understood. To approach this problem, we measured 4701 circulating human protein …
understood. To approach this problem, we measured 4701 circulating human protein …
Genetic insights into the association between serum cytokines and frozen shoulder risk: a bidirectional Mendelian randomization study
X Li, H Long, D Wen, B Chen, L Chen, B Li - Cytokine, 2024 - Elsevier
Background Although existing studies have indicated a connection between chronic low-
grade inflammation and the onset of frozen shoulder (FS), the precise causal relationship …
grade inflammation and the onset of frozen shoulder (FS), the precise causal relationship …
MR Corge: sensitivity analysis of Mendelian randomization based on the core gene hypothesis for polygenic exposures
Mendelian randomization is being utilized to assess causal effects of polygenic exposures,
where many genetic instruments are subject to horizontal pleiotropy. Existing methods for …
where many genetic instruments are subject to horizontal pleiotropy. Existing methods for …