Abstract Nucleophosmin 1 (NPM1) is a nucleus-cytoplasmic shuttling protein which is
predominantly located in the nucleolus and exerts multiple functions, including regulation of …

Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

Heatmap is a widely used statistical visualization method on matrix‐like data to reveal
similar patterns shared by subsets of rows and columns. In the R programming language …

We generated ex vivo drug-response and multiomics profiling data for a prospective series
of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision …

Background Relatlimab plus nivolumab (anti–lymphocyte-activation gene 3 plus anti–
programmed death 1 [anti–LAG-3+ anti–PD-1]) has been approved by the FDA as a first-line …

Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …

Hematopoietic cell transplantation from HLA-haploidentical related donors is increasingly
used to treat hematologic cancers; however, characteristics of the optimal haploidentical …

Background Immune exhaustion and senescence are dominant dysfunctional states of
effector T cells and major hurdles for the success of cancer immunotherapy. In the current …

Cancer cells can evade natural killer (NK) cell activity, thereby limiting anti-tumor immunity.
To reveal genetic determinants of susceptibility to NK cell activity, we examined interacting …

Myeloid neoplasms with erythroid or megakaryocytic differentiation include pure erythroid
leukemia, myelodysplastic syndrome with erythroid features, and acute megakaryoblastic …