In autoimmune diseases, recognition of self-antigens presented by major histocompatibility
complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or …

Our understanding of the immunopathological features of type 1 diabetes (T1D) has greatly
improved over the past two decades and has shed light on disease heterogeneity dictated …

Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β cell autoimmunity
and type 1 diabetes. We investigated how CVB affects human β cells and anti-CVB T cell …

Inflammation, including reactive oxygen species and inflammatory cytokines in tissues
amplify various post-translational modifications of self-proteins. A number of post …

Type 1 diabetes (T1D) is an autoimmune disease that develops in the interplay between
genetic and environmental factors. A majority of individuals who develop T1D have a HLA …

Self-antigens, benign autoimmunity and type 1 diabetes: a be... : Current Opinion in
Endocrinology, Diabetes and Obesity Self-antigens, benign autoimmunity and type 1 diabetes …

In type 1 diabetes, the insulin-producing beta cells of the pancreas are destroyed through
the activity of autoreactive T cells. In addition to strong and well-documented HLA class II …

Epithelial ovarian cancer (EOC) has not significantly benefited from advances in
immunotherapy, mainly because of the lack of well-defined actionable antigen targets. Using …

T-cell receptors (TCRs) are formed by stochastic gene rearrangements, theoretically
generating> 10 19 sequences. They are selected during thymopoiesis, which releases a …

Background Post-translational modification of proteins has the potential to alter the ability of
T cells to recognize major histocompatibility complex (MHC) class-I and class-II restricted …